Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Perampanel
Drug ID BADD_D01733
Description Perampanel is a noncompetitive AMPA glutamate receptor antagonist. It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures. The FDA label includes an important black-boxed warning of serious or life-threatening behavioral and psychiatric reactions in patients taking Fycompa™.
Indications and Usage Used in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures.
Marketing Status Prescription
ATC Code N03AX22
DrugBank ID DB08883
KEGG ID D08964
MeSH ID C551441
PubChem ID 9924495
TTD Drug ID D0U3ED
NDC Product Code 62856-278; 62856-272; 50379-0020; 62856-276; 67835-0026; 60510-609; 11071-907; 11071-906; 11071-905; 60510-606; 11071-902; 62856-274; 60510-605; 11071-904; 60510-608; 60510-604; 47848-049; 62856-280; 62856-282; 60510-607; 11071-903; 62856-290
Synonyms perampanel | 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one | perampanel hydrate | perampanel hydrate (4:3) | E-2007 | E2007 | ER-155055-90 | Fycompa
Chemical Information
Molecular Formula C23H15N3O
CAS Registry Number 380917-97-5
SMILES C1=CC=C(C=C1)N2C=C(C=C(C2=O)C3=CC=CC=C3C#N)C4=CC=CC=N4
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Irritability19.04.02.013; 08.01.03.011--
Laceration12.01.06.006; 23.03.11.004--Not Available
Ligament sprain15.07.02.004; 12.01.07.008--Not Available
Memory impairment19.20.01.003; 17.03.02.003--
Mood altered19.04.02.007--Not Available
Mood swings19.04.03.001--Not Available
Musculoskeletal pain15.03.04.007--
Myalgia15.05.02.001--
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Osteoarthritis15.01.04.001--Not Available
Pain in extremity15.03.04.010--
Paraesthesia17.02.06.005--
Rash23.03.13.001--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urinary tract infection20.08.02.001; 11.01.14.004--
Vertigo04.04.01.003; 17.02.12.002--
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.003--
Weight increased13.15.01.006--
Balance disorder17.02.02.007--Not Available
Contusion15.03.01.008; 12.01.06.001; 24.07.06.001; 23.03.11.002--
Musculoskeletal discomfort15.03.04.001--Not Available
Affect lability19.04.01.001--Not Available
Connective tissue disorder15.06.01.006--Not Available
Infestation23.09.05.001; 11.09.01.001--Not Available
Limb injury12.01.09.008--Not Available
Malnutrition14.03.02.004--Not Available
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