Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pazopanib
Drug ID BADD_D01687
Description Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Indications and Usage Treatment of advanced renal cell cancer and advanced soft tissue sarcoma (in patients previously treated with chemotherapy)
Marketing Status Prescription; Discontinued
ATC Code L01EX03
DrugBank ID DB06589
KEGG ID D05380
MeSH ID C516667
PubChem ID 10113978
TTD Drug ID Not Available
NDC Product Code Not Available
Synonyms pazopanib | GW 786034B | GW786034B | GW-786034B | GW 780604 | GW780604 | GW-780604 | Votrient
Chemical Information
Molecular Formula C21H23N7O2S
CAS Registry Number 444731-52-6
SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Endocrine disorder05.09.01.001--Not Available
Enterocolitis07.08.03.0030.001332%
Eosinophilia01.02.04.001--
Epilepsy17.12.03.002--Not Available
Epistaxis24.07.01.005; 22.04.03.0010.011722%
Eructation07.01.02.0030.000533%
Erythema23.03.06.001--Not Available
Erythema multiforme10.01.03.015; 23.03.01.0030.001066%
Eye disorder06.08.03.001--Not Available
Eye haemorrhage24.07.05.002; 06.07.02.0010.000799%Not Available
Eye pain06.08.03.002--
Eye swelling06.08.03.003--Not Available
Eyelid oedema23.04.01.003; 10.01.05.001; 06.04.04.004--Not Available
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.003--
Facial paralysis17.04.03.0080.001598%Not Available
Faeces discoloured07.01.03.0020.001865%Not Available
Fatigue08.01.01.0020.111893%
Febrile neutropenia08.05.02.004; 01.02.03.002--
Feeling abnormal08.01.09.014--Not Available
Feeling cold08.01.09.0080.001332%Not Available
Feeling drunk08.01.09.0150.000533%Not Available
Feeling hot08.01.09.009--Not Available
Femur fracture12.04.01.003; 15.08.03.003--Not Available
Fistula15.03.02.0010.000347%Not Available
Flank pain20.02.03.006; 15.03.04.003; 08.01.08.0070.001865%
Flatulence07.01.04.0020.005062%
Fluid overload02.05.04.004; 14.05.06.0010.000799%Not Available
Fluid retention20.01.02.003; 14.05.06.002--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Food allergy10.01.01.0120.001066%Not Available
The 7th Page    First    Pre   7 8 9 10 11    Next   Last    Total 28 Pages