Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Pazopanib
Drug ID BADD_D01687
Description Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Indications and Usage Treatment of advanced renal cell cancer and advanced soft tissue sarcoma (in patients previously treated with chemotherapy)
Marketing Status approved
ATC Code L01EX03
DrugBank ID DB06589
KEGG ID D05380
MeSH ID C516667
PubChem ID 10113978
TTD Drug ID Not Available
NDC Product Code Not Available
UNII 7RN5DR86CK
Synonyms pazopanib | GW 786034B | GW786034B | GW-786034B | GW 780604 | GW780604 | GW-780604 | Votrient
Chemical Information
Molecular Formula C21H23N7O2S
CAS Registry Number 444731-52-6
SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hemiplegia17.01.04.0020.000224%Not Available
Hepatic failure09.01.03.0020.001757%
Hepatic function abnormal09.01.02.0010.004634%Not Available
Hepatic haemorrhage12.01.17.009; 24.07.01.027; 09.01.06.0080.000168%
Hepatic necrosis09.01.07.0020.000112%
Hepatic neoplasm16.07.03.001; 09.04.03.0010.000280%Not Available
Hepatitis09.01.07.0040.000951%Not Available
Hepatitis acute09.01.07.0050.000280%Not Available
Hepatitis cholestatic09.01.01.0020.000112%Not Available
Hepatitis toxic12.03.01.016; 09.01.07.0170.000112%Not Available
Hepatocellular injury09.01.07.0080.001623%Not Available
Hepatomegaly09.01.05.0010.000168%Not Available
Hepatotoxicity09.01.07.009; 12.03.01.0080.003481%Not Available
Hernia08.01.04.0010.000437%Not Available
Hiccups22.12.01.001; 07.01.06.0090.000168%
Hydrocephalus17.07.01.0010.000112%
Hydronephrosis20.01.05.0010.000224%Not Available
Hyperaesthesia23.03.03.080; 17.02.06.0040.000381%Not Available
Hyperammonaemia14.10.01.001; 09.01.02.0020.000112%Not Available
Hyperbilirubinaemia14.11.01.010; 01.06.04.003; 09.01.01.0030.000839%Not Available
Hypercalcaemia14.04.01.003; 05.04.01.0020.000862%
Hyperchlorhydria07.11.03.0010.000302%Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperkalaemia14.05.03.0010.001063%
Hyperkeratosis23.01.01.0010.000851%
Hypertension24.08.02.0010.031665%
Hypertensive crisis24.08.01.0010.001287%Not Available
Hypertensive encephalopathy24.08.05.001; 17.13.02.0020.000112%Not Available
Hyperthyroidism14.11.01.011; 05.02.02.0010.001455%
Hypertriglyceridaemia14.08.02.0010.000280%
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