Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Panitumumab
Drug ID BADD_D01666
Description Panitumumab (ABX-EGF) is a recombinant human IgG2 monoclonal antibody that binds specifically to the human epidermal growth factor receptor (EGFR). This drug is an antineoplastic agent. Panitumumab was granted FDA approval on 27 September 2006.[L17663]
Indications and Usage For the treatment of EGFR-expressing, metastatic colorectal carcinoma that is refractory to fluoropyrimidine-, oxaliplatin-, and irinotecan- containing chemotherapy regimens.
Marketing Status Prescription
ATC Code L01FE02
DrugBank ID DB01269
KEGG ID D05350
MeSH ID D000077544
PubChem ID Not Available
TTD Drug ID D0HU9H
NDC Product Code 55513-954; 55513-956
Synonyms Panitumumab | Panitumumab Antibody, Human | Human Panitumumab Antibody | ABX-EGF MAb | ABX-EGF Monoclonal Antibody | ABX EGF Monoclonal Antibody | Monoclonal Antibody, ABX-EGF | Vectibix
Chemical Information
Molecular Formula Not Available
CAS Registry Number 339177-26-3
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abscess11.01.08.001--Not Available
Acne23.02.01.001--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Chills15.05.03.016; 08.01.09.001--
Conjunctivitis11.01.06.012; 06.04.01.002--
Constipation07.02.02.001--
Cough22.02.03.001--
Death08.04.01.001--
Dermatitis acneiform23.02.01.004--
Dermatitis allergic23.03.04.003; 10.01.03.014--Not Available
Diarrhoea07.02.01.001--
Dry skin23.03.03.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Erythema23.03.06.001--Not Available
Eye disorder06.08.03.001--Not Available
Eye irritation06.04.05.003--Not Available
Fatigue08.01.01.002--
Hair disorder23.02.06.003--Not Available
Hypersensitivity10.01.03.003--
Hypomagnesaemia14.04.02.001--
Keratitis06.04.02.002--
Lacrimation increased06.08.02.004--
Mucosal inflammation08.01.06.002--Not Available
Nail disorder23.02.05.002--
Nausea07.01.07.001--
Necrotising fasciitis15.03.03.004; 11.01.17.002--Not Available
Ocular hyperaemia06.04.05.004--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
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