Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Necrotising fasciitis
ADR ID BADD_A02985
ADR Hierarchy
11      Infections and infestations
11.01      Infections - pathogen unspecified
11.01.17      Muscle and soft tissue infections
11.01.17.002      Necrotising fasciitis
15      Musculoskeletal and connective tissue disorders
15.03      Musculoskeletal and connective tissue disorders NEC
15.03.03      Musculoskeletal and connective tissue infections and inflammations NEC
15.03.03.004      Necrotising fasciitis
Description An acute necrotic infection of the SCROTUM; PENIS; or PERINEUM. It is characterized by scrotum pain and redness with rapid progression to gangrene and sloughing of tissue. Fournier gangrene is usually secondary to perirectal or periurethral infections associated with local trauma, operative procedures, or urinary tract disease. [MeSH]
MedDRA Code 10028885
MeSH ID D018934; D019115
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Fasciitis necrotising | Fournier's gangrene | Melenay's syndrome | Necrotising fasciitis | Necrotising fasciitis NOS | Fasciitis necrotizing | Necrotizing fasciitis | Fournier Gangrene | Gangrene, Fournier | Fournier's Disease | Fourniers Disease | Fournier's Gangrene | Fourniers Gangrene | Gangrene, Fournier's | Fournier Disease
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00194Azacitidine0.000486%
BADD_D00286Bosutinib0.000139%
BADD_D00344Canagliflozin0.015318%
BADD_D00410Celecoxib0.000060%
BADD_D00490Clobetasol propionate0.000104%
BADD_D00511Clozapine0.019617%
BADD_D00551Cyclosporine0.000779%
BADD_D00560Cytarabine0.000799%
BADD_D00564Dabigatran etexilate--
BADD_D00578Dapagliflozin0.013264%
BADD_D00581Daptomycin0.000213%
BADD_D00623Dexamethasone0.000269%
BADD_D00653Diclofenac0.000593%
BADD_D00666Diflunisal--
BADD_D00680Dimethyl fumarate--
BADD_D00765Empagliflozin0.044917%
BADD_D00782Epinephrine0.000579%
BADD_D01119Ibrutinib0.000799%
BADD_D01120Ibuprofen0.000037%
BADD_D01136Imatinib0.000799%
BADD_D01156Indomethacin--
BADD_D01231Ketoprofen0.005399%
BADD_D01232Ketorolac0.000459%
BADD_D01240Lactulose0.000315%
BADD_D01253Lenalidomide--
BADD_D01254Lenvatinib0.000533%
BADD_D01393Meropenem0.000213%
BADD_D01401Metformin0.000078%
BADD_D01433Methylprednisolone0.000142%
BADD_D01435Methylprednisolone hemisuccinate0.013989%
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