Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Nevirapine
Drug ID BADD_D01557
Description A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class.
Indications and Usage For use in combination with other antiretroviral drugs in the ongoing treatment of HIV-1 infection.
Marketing Status approved
ATC Code J05AG01
DrugBank ID DB00238
KEGG ID D00435
MeSH ID D019829
PubChem ID 4463
TTD Drug ID D0O2EM
NDC Product Code 53104-7546; 70159-002; 65862-027; 0378-4050; 64380-709; 65862-932; 65862-933; 31722-505; 65862-057; 68554-0044; 33342-004; 0597-0047; 64220-102; 0378-4890; 65162-209; 33342-238; 42571-131
UNII 99DK7FVK1H
Synonyms Nevirapine | Nevirapine Hemihydrate | Hemihydrate, Nevirapine | Viramune | BI-RG-587 | BI RG 587 | BIRG587
Chemical Information
Molecular Formula C15H14N4O
CAS Registry Number 129618-40-2
SMILES CC1=C2C(=NC=C1)N(C3=C(C=CC=N3)C(=O)N2)C4CC4
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hepatic necrosis09.01.07.002--
Hepatitis09.01.07.004--Not Available
Hepatitis acute09.01.07.0050.003978%Not Available
Hepatitis cholestatic09.01.01.0020.005304%Not Available
Hepatitis fulminant09.01.07.007; 11.07.01.003--Not Available
Hepatitis toxic12.03.01.016; 09.01.07.017--Not Available
Hepatocellular injury09.01.07.0080.003978%Not Available
Hepatotoxicity12.03.01.008; 09.01.07.0090.005304%Not Available
Hypercholesterolaemia14.08.01.001--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperlactacidaemia14.01.01.006--Not Available
Hypersensitivity10.01.03.0030.002652%
Hypertension24.08.02.0010.007956%
Hypertriglyceridaemia14.08.02.001--
Immune system disorder10.02.01.001--Not Available
Influenza like illness08.01.03.0100.005304%
Insulin resistance14.06.02.003; 05.06.02.003--Not Available
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Liver disorder09.01.08.001--Not Available
Liver function test abnormal13.03.04.030--Not Available
Lymphadenopathy01.09.01.002--Not Available
Malaise08.01.01.003--
Mouth ulceration07.05.06.0040.002652%Not Available
Myalgia15.05.02.0010.002652%
Myocardial infarction24.04.04.009; 02.02.02.0070.013260%
Nausea07.01.07.001--
Necrosis24.04.02.006; 08.03.03.001--Not Available
Neoplasm malignant16.16.01.0010.002652%Not Available
Nervous system disorder17.02.10.001--Not Available
Neuropathy peripheral17.09.03.003--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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