Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nepafenac
Drug ID BADD_D01555
Description Nepafenac is a non-steroidal anti-inflammatory prodrug (NSAID) usually sold as a prescription eye drop. It is used to treat pain and inflammation associated with cataract surgery.
Indications and Usage For the treatment of pain and inflammation associated with cataract surgery.
Marketing Status Prescription
ATC Code S01BC10
DrugBank ID DB06802
KEGG ID D05143
MeSH ID C414203
PubChem ID 151075
TTD Drug ID D02IHW
NDC Product Code 69988-0005; 0078-0743; 53296-0099; 64181-0019; 42571-353; 73309-311; 0065-0002; 58567-104
Synonyms nepafenac | 2-amino-3-benzoylbenzeneacetamide | Nevanac
Chemical Information
Molecular Formula C15H14N2O2
CAS Registry Number 78281-72-8
SMILES C1=CC=C(C=C1)C(=O)C2=CC=CC(=C2N)CC(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Eye disorder06.08.03.001--Not Available
Eye inflammation06.04.05.0020.002022%Not Available
Eye irritation06.04.05.0030.006739%Not Available
Eye pain06.08.03.0020.013477%
Eye swelling06.08.03.0030.004043%Not Available
Eyelid oedema06.04.04.004; 23.04.01.003; 10.01.05.0010.002695%Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.0140.003369%Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Headache17.14.01.0010.002695%
Hypersensitivity10.01.03.0030.001348%
Hypertension24.08.02.001--
Immune system disorder10.02.01.001--Not Available
Impaired healing08.03.02.001--Not Available
Injury corneal12.01.04.018; 06.11.03.0020.001348%Not Available
Intraocular pressure increased13.07.04.002--Not Available
Iritis10.02.01.022; 06.04.03.002--Not Available
Keratitis06.04.02.002--
Lacrimation decreased06.08.02.007--Not Available
Lacrimation increased06.08.02.0040.002695%
Lenticular opacities06.06.01.003--Not Available
Macular oedema06.04.06.0050.003369%Not Available
Malaise08.01.01.003--
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Night blindness14.12.03.001; 06.02.02.0030.001348%
Ocular hyperaemia06.04.05.0040.010108%Not Available
Pain in extremity15.03.04.0100.001348%
Palpitations02.01.02.0030.002022%
Photophobia17.17.02.006; 06.01.01.0040.001348%
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