Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nafcillin
Drug ID BADD_D01515
Description A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be used as a first-line therapy in Methicillin-Sensitive *Staphylococcus aureus* infections [A20360].
Indications and Usage Indicated in the treatment of infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug.
Marketing Status Prescription; Discontinued
ATC Code J01CF06
DrugBank ID DB00607
KEGG ID D08242
MeSH ID D009254
PubChem ID 8982
TTD Drug ID D0A0JH
NDC Product Code 44567-221; 44567-223; 0409-3713; 0781-3126; 0781-9124; 44567-222; 0338-1017; 0338-1019; 0409-3714; 0409-3715; 0781-3124; 0781-9125; 0781-9126; 63323-330; 0781-3125
Synonyms Nafcillin | Naphthamidopenicillin | Nafcil | Nafcillin Sodium | Sodium, Nafcillin | Nafcillin, Monosodium Salt, Anhydrous | Sodium Nafcillin | Nafcillin, Sodium
Chemical Information
Molecular Formula C21H22N2O5S
CAS Registry Number 147-52-4
SMILES CCOC1=C(C2=CC=CC=C2C=C1)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pain08.01.08.004--
Pancytopenia01.03.03.003--Not Available
Phlebitis24.05.03.001; 12.02.01.002--
Proteinuria20.02.01.011--
Pruritus23.03.12.0010.000639%
Pseudomembranous colitis11.02.02.002; 07.19.01.003--Not Available
Pyrexia08.05.02.0030.000426%
Rash23.03.13.0010.001171%Not Available
Rash erythematous23.03.06.0030.000213%Not Available
Rash generalised23.03.13.0020.000319%Not Available
Rash pruritic23.03.12.0020.000213%Not Available
Renal failure20.01.03.0050.000056%Not Available
Renal tubular disorder20.05.03.004--Not Available
Respiratory arrest22.02.01.0090.000056%Not Available
Sepsis11.01.11.0030.000056%
Serum sickness12.02.08.004; 10.01.03.004--
Shock24.06.02.002--Not Available
Skin exfoliation23.03.07.003--Not Available
Skin necrosis23.03.03.011--Not Available
Stomatitis07.05.06.005--
Swelling08.01.03.0150.000213%Not Available
Swollen tongue23.04.01.014; 10.01.05.015; 07.14.02.0030.000213%Not Available
Thrombophlebitis24.01.02.001--Not Available
Tongue discolouration07.14.02.006--Not Available
Urticaria10.01.06.001; 23.04.02.0010.000426%
Vomiting07.01.07.0030.000639%
Weight decreased13.15.01.0050.000319%
White blood cell count decreased13.01.06.0120.000213%
Yellow skin23.03.03.042; 09.01.01.009; 08.01.03.0460.000213%Not Available
Tubulointerstitial nephritis20.05.02.0020.001384%Not Available
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