Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nafcillin
Drug ID BADD_D01515
Description A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be used as a first-line therapy in Methicillin-Sensitive *Staphylococcus aureus* infections [A20360].
Indications and Usage Indicated in the treatment of infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug.
Marketing Status Prescription; Discontinued
ATC Code J01CF06
DrugBank ID DB00607
KEGG ID D08242
MeSH ID D009254
PubChem ID 8982
TTD Drug ID D0A0JH
NDC Product Code 44567-221; 44567-223; 0409-3713; 0781-3126; 0781-9124; 44567-222; 0338-1017; 0338-1019; 0409-3714; 0409-3715; 0781-3124; 0781-9125; 0781-9126; 63323-330; 0781-3125
Synonyms Nafcillin | Naphthamidopenicillin | Nafcil | Nafcillin Sodium | Sodium, Nafcillin | Nafcillin, Monosodium Salt, Anhydrous | Sodium Nafcillin | Nafcillin, Sodium
Chemical Information
Molecular Formula C21H22N2O5S
CAS Registry Number 147-52-4
SMILES CCOC1=C(C2=CC=CC=C2C=C1)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Haematochezia24.07.02.012; 07.12.02.0030.000213%Not Available
Haematuria24.07.01.047; 20.02.01.006--
Haemoglobin decreased13.01.05.0030.000213%Not Available
Heart rate increased13.14.04.0020.000213%Not Available
Hepatic failure09.01.03.0020.000213%
Hepatitis cholestatic09.01.01.0020.000426%Not Available
Hepatotoxicity12.03.01.008; 09.01.07.0090.000958%Not Available
Hyperhidrosis23.02.03.004; 08.01.03.0280.000213%
Hyperkalaemia14.05.03.0010.000213%
Hypersensitivity10.01.03.0030.000532%
Hypersensitivity vasculitis01.01.04.008; 24.05.02.012; 23.06.02.005; 10.02.02.0170.000426%Not Available
Hypokalaemia14.05.03.0020.000639%
Hypotension24.06.03.0020.000426%
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.0040.000639%Not Available
Jaundice cholestatic09.01.01.0050.000056%Not Available
Laryngeal oedema23.04.01.005; 10.01.05.003; 22.04.02.001--
Laryngospasm22.04.02.002--
Leukocytosis01.02.01.0020.000213%
Liver function test abnormal13.03.01.013--Not Available
Local reaction08.01.03.012--Not Available
Malaise08.01.01.003--
Myalgia15.05.02.001--
Nausea07.01.07.0010.000639%
Necrosis24.04.02.006; 08.03.03.001--Not Available
Nephritis20.05.02.0010.000532%Not Available
Nephropathy20.05.03.001--Not Available
Neurotoxicity17.02.10.002; 12.03.01.011--Not Available
Neutropenia01.02.03.0040.000213%Not Available
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