Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Mitotane
Drug ID BADD_D01479
Description A derivative of the insecticide dichlorodiphenyldichloroethane that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Indications and Usage For treatment of inoperable adrenocortical tumours; Cushing's syndrome
Marketing Status Prescription
ATC Code L01XX23
DrugBank ID DB00648
KEGG ID D00420
MeSH ID D008939
PubChem ID 4211
TTD Drug ID D0Z5OE
NDC Product Code 62991-2604; 38779-2263; 21222-002; 14799-2009; 51927-3826; 49452-4786; 43744-366; 72969-051; 71052-048; 76336-080
Synonyms Mitotane | o,p-DDD | Mytotan | ortho,para-DDD | ortho,para DDD | Chlodithane | Lysodren | Chloditan | Khloditan
Chemical Information
Molecular Formula C14H10Cl4
CAS Registry Number 53-19-0
SMILES C1=CC=C(C(=C1)C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Endocrine disorder05.09.01.001--Not Available
Eye disorder06.08.03.001--Not Available
Feeling abnormal08.01.09.014--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Fungal infection11.03.05.001--Not Available
Gamma-glutamyltransferase increased13.03.01.0110.000533%
Gastrointestinal disorder07.11.01.001--Not Available
Gynaecomastia05.05.02.003; 21.05.04.003--
Haematuria24.07.01.047; 20.02.01.006--
Headache17.14.01.001--
Hepatitis09.01.07.004--Not Available
Hepatitis cholestatic09.01.01.002--Not Available
Hepatocellular injury09.01.07.008--Not Available
Hypercholesterolaemia14.08.01.0010.000533%Not Available
Hyperpyrexia08.05.02.002--Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypertriglyceridaemia14.08.02.001--
Hypotension24.06.03.002--
Hypothyroidism14.11.01.012; 05.02.03.0010.000799%
Hypouricaemia14.09.01.006--Not Available
Infection11.01.08.002--Not Available
Injury12.01.08.004--Not Available
Iron deficiency anaemia14.13.02.001; 01.03.01.0020.000533%Not Available
Irritability19.04.02.013; 08.01.03.011--
Lenticular opacities06.06.01.003--Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Maculopathy06.09.03.007--Not Available
Menorrhagia21.01.03.0020.000533%
Mental disability26.01.01.001--Not Available
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