Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Metoclopramide hydrochloride
Drug ID BADD_D01443
Description Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system.[A184934] Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition to gastroesophageal reflux disease (GERD). It can also be used to prevent nausea or vomiting associated with chemotherapy or certain surgical or diagnostic procedures.[L8417] One unique property of this drug is that it does not increase gastric acid secretion. It is available in the oral tablet form or in solution, and can also be administered through the intravenous route.[T683] Metoclopramide was initially approved by the FDA in 1980.[A184922]
Indications and Usage For the treatment of gastroesophageal reflux disease (GERD). It is also used in treating nausea and vomiting, and to increase gastric emptying.
Marketing Status Prescription; Discontinued
ATC Code A03FA01
DrugBank ID DB01233
KEGG ID D02213
MeSH ID D008787
PubChem ID 23659
TTD Drug ID D08VYV
NDC Product Code 76045-213; 72089-307; 68071-4551; 0121-1576; 49452-4715; 0121-0576; 76045-101; 0404-9910; 55154-2353; 62559-166; 71872-7265; 55154-0450; 51552-1549; 51604-0005; 17856-0576; 68071-3262; 66689-031; 52584-414; 23155-240; 61919-150; 68788-6791; 40700-0010; 51927-5099; 43386-581; 43386-580; 51927-0185; 57451-1119; 57451-1139; 62559-165; 45562-1737; 76420-295
Synonyms Metoclopramide | 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide | Metaclopramide | Maxolon | Rimetin | Metoclopramide Hydrochloride | Hydrochloride, Metoclopramide | Metoclopramide Monohydrochloride | Monohydrochloride, Metoclopramide | Metoclopramide Monohydrochloride, Monohydrate | Primperan | Reglan | Cerucal | Metoclopramide Dihydrochloride | Dihydrochloride, Metoclopramide
Chemical Information
Molecular Formula C14H23Cl2N3O2
CAS Registry Number 2576-84-3
SMILES CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agranulocytosis01.02.03.001--Not Available
Akathisia19.06.02.006; 17.01.02.002--
Altered state of consciousness19.07.01.003; 17.02.04.001--Not Available
Amenorrhoea21.01.02.001; 05.05.01.002--
Angioedema10.01.05.009; 23.04.01.001--Not Available
Atrioventricular block02.03.01.002--Not Available
Autonomic nervous system imbalance24.06.01.005; 17.05.01.011; 08.01.01.010--Not Available
Bradycardia02.03.02.002--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Cardiac failure congestive02.05.01.002--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Depression19.15.01.001--
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dyskinesia17.01.02.006--
Dyspnoea22.02.01.004; 02.01.03.002--
Dystonia17.01.03.001--Not Available
Fatigue08.01.01.002--
Fluid retention14.05.06.002; 20.01.02.003--Not Available
Galactorrhoea21.05.02.002; 05.03.04.002--Not Available
Gynaecomastia21.05.04.003; 05.05.02.003--
Hallucination19.10.02.002--
Headache17.14.01.001--
Hepatotoxicity12.03.01.008; 09.01.07.009--Not Available
Hypertension24.08.02.001--
Hyperthermia12.05.01.002; 08.05.01.001--Not Available
Hypotension24.06.03.002--
Incontinence17.05.01.006; 07.01.06.011; 20.02.02.004--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Laryngeal oedema23.04.01.005; 22.04.02.001; 10.01.05.003--
The 1th Page    1 2    Next   Last    Total 2 Pages