Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Metoclopramide
Drug ID BADD_D01442
Description Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system.[A184934] Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition to gastroesophageal reflux disease (GERD). It can also be used to prevent nausea or vomiting associated with chemotherapy or certain surgical or diagnostic procedures.[L8417] One unique property of this drug is that it does not increase gastric acid secretion. It is available in the oral tablet form or in solution, and can also be administered through the intravenous route.[T683] Metoclopramide was initially approved by the FDA in 1980.[A184922]
Indications and Usage For the treatment of gastroesophageal reflux disease (GERD). It is also used in treating nausea and vomiting, and to increase gastric emptying.
Marketing Status Prescription; Discontinued
ATC Code A03FA01
DrugBank ID DB01233
KEGG ID D00726
MeSH ID D008787
PubChem ID 4168
TTD Drug ID D08VYV
NDC Product Code 63187-404; 51079-888; 0093-2204; 51662-1367; 0615-8285; 63629-2144; 70518-0669; 42291-596; 60687-620; 55154-8196; 0409-3414; 43353-274; 51662-1288; 70518-1193; 66267-841; 71872-7075; 62559-190; 62559-295; 71872-7076; 68084-676; 60687-631; 71335-0362; 42291-595; 68788-7930; 50090-0132; 55154-4383; 66267-286; 49884-689; 68071-4569; 68788-7226; 0703-4502; 67296-0855; 62559-296; 63187-235; 0615-7698; 71335-0790; 0093-2203; 49999-057; 66267-827; 68071-4326; 51079-886; 50090-2221; 63629-7967; 63629-1961; 63629-8745
Synonyms Metoclopramide | 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide | Metaclopramide | Maxolon | Rimetin | Metoclopramide Hydrochloride | Hydrochloride, Metoclopramide | Metoclopramide Monohydrochloride | Monohydrochloride, Metoclopramide | Metoclopramide Monohydrochloride, Monohydrate | Primperan | Reglan | Cerucal | Metoclopramide Dihydrochloride | Dihydrochloride, Metoclopramide
Chemical Information
Molecular Formula C14H22ClN3O2
CAS Registry Number 364-62-5
SMILES CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Emotional disorder19.04.02.0050.024644%Not Available
Encephalopathy17.13.02.001--
Epilepsy17.12.03.002--Not Available
Epistaxis24.07.01.005; 22.04.03.001--
Eructation07.01.02.0030.001087%
Erythema23.03.06.001--Not Available
Essential tremor17.01.06.0040.012685%Not Available
Extrapyramidal disorder17.01.02.0070.108536%
Fatigue08.01.01.002--
Fear19.06.03.0010.004349%Not Available
Febrile neutropenia08.05.02.004; 01.02.03.002--
Feeling abnormal08.01.09.014--Not Available
Feeling jittery08.01.09.016--Not Available
Fluid retention20.01.02.003; 14.05.06.002--Not Available
Flushing08.01.03.025; 24.03.01.002; 23.06.05.003--
Gait disturbance17.02.05.016; 08.01.02.002--
Galactorrhoea05.03.04.002; 21.05.02.002--Not Available
Gastritis07.08.02.0010.001087%
Gastrooesophageal reflux disease07.02.02.003--
Gastrointestinal disorder07.11.01.001--Not Available
Generalised tonic-clonic seizure17.12.01.0020.002537%Not Available
Gynaecomastia21.05.04.003; 05.05.02.003--
Hallucination19.10.02.002--
Headache17.14.01.001--
Hepatic failure09.01.03.0020.000567%
Hepatitis acute09.01.07.0050.000725%Not Available
Hepatocellular injury09.01.07.008--Not Available
Hepatotoxicity12.03.01.008; 09.01.07.009--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperprolactinaemia05.03.01.002--Not Available
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