Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Methylprednisolone acetate
Drug ID BADD_D01434
Description Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone].[A188811] It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957.[L10785] In the outbreak of COVID-19, low dose methylprednisolone-based therapy was successful in treating COVID-19-associated pneumonia in one patient with long-term immunosuppression.[A192813] The efficacy of methylprednisolone in novel coronavirus pneumonia is being investigated further in clinical trials.[L12666]
Indications and Usage Adjunctive therapy for short-term administration in rheumatoid arthritis.
Marketing Status Prescription; Discontinued
ATC Code D07AA01; D10AA02; H02AB04
DrugBank ID DB00959
KEGG ID D00979
MeSH ID D000077555
PubChem ID 5877
TTD Drug ID Not Available
NDC Product Code 50090-0436; 0009-0306; 0009-3475; 38779-0144; 50090-4802; 70518-2894; 50090-0312; 46439-8767; 0009-0274; 60219-1573; 25021-821; 0009-0280; 0009-3073; 50090-0556; 70518-2914; 63187-474; 50090-5894; 16714-089; 0703-0045; 25021-820; 0703-0043; 76420-081; 0703-0063; 70518-2965; 51927-0000; 16714-472; 51552-0958; 70518-2459; 70518-3071; 70121-1552; 50090-1823; 16714-473; 49452-4688; 0703-0051; 70121-1573; 51662-1429; 0009-0026; 76420-260; 0703-0031; 10695-041; 76420-262; 16714-090; 22552-0023; 63275-9942; 68788-8082; 60219-1574; 70121-1574; 70518-2915; 50090-2098; 65089-0016; 16714-088; 82298-117; 52128-148
Synonyms Methylprednisolone Acetate | Methylprednisolone-21-acetate | Methylprednisolone 21 acetate | Acetyl-Methylprednisolone | Acetyl Methylprednisolone | Depo-Medrone | Depo Medrone | Depo-Medrol | Depo Medrol | Methylprednisolone Acetate, (11beta,16beta)-isomer | Methylprednisolone Acetate, (11beta,16alpha)-isomer
Chemical Information
Molecular Formula C24H32O6
CAS Registry Number 53-36-1
SMILES CC1CC2C3CCC(C3(CC(C2C4(C1=CC(=O)C=C4)C)O)C)(C(=O)COC(=O)C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cardiac arrest02.03.04.001--
Cardiac failure congestive02.05.01.002--Not Available
Cardiomegaly02.04.02.001--Not Available
Cataract06.06.01.001--
Cataract subcapsular06.06.01.002--Not Available
Circulatory collapse24.06.02.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Cushingoid19.07.03.001; 14.11.01.006; 05.01.01.002; 24.08.02.004--
Delusion19.10.01.001--
Depressed mood19.15.02.001--Not Available
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis allergic23.03.04.003; 10.01.03.014--Not Available
Diabetes mellitus05.06.01.001; 14.06.01.001--Not Available
Diarrhoea07.02.01.001--
Diplegia17.01.04.015--Not Available
Discomfort08.01.08.003--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Drug dependence19.07.02.009--Not Available
Dry skin23.03.03.001--
Dyspepsia07.01.02.001--
Ear disorder04.03.01.001--Not Available
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.001--Not Available
Endocrine disorder05.09.01.001--Not Available
Erythema23.03.06.001--Not Available
Euphoric mood19.04.02.006--
Exophthalmos06.09.04.001; 05.02.02.002--Not Available
Eye allergy10.01.03.028; 06.04.05.010--Not Available
Eye disorder06.08.03.001--Not Available
Eye inflammation06.04.05.002--Not Available
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