Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Methylphenidate hydrochloride
Drug ID BADD_D01432
Description Methylphenidate is a central nervous system stimulant used most commonly in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and for narcolepsy. Also known as the marketed products Ritalin, Concerta, or Biphentin, methylphenidate is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve the following group of developmentally inappropriate symptoms associated with ADHD: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity. Long-acting formulations of psychostimulants such as methylphenidate, [DB01576], and [DB01255] are considered the most effective and widely used treatment for ADHD, and are considered first-line options for children, adolescents, and adults as recommended by CADDRA (Canadian ADHD Resource Alliance). [L6037] CADDRA recommends the use of methylphenidate due to long term studies, of over twenty years in duration, which show methylphenidate is safe and effective.
Indications and Usage For use as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity.
Marketing Status Prescription; Discontinued
ATC Code N06BA04
DrugBank ID DB00422
KEGG ID D01296
MeSH ID D008774
PubChem ID 9280
TTD Drug ID D02PPN
NDC Product Code 59116-3393; 43547-487; 0527-4581; 47781-416; 51862-614; 31722-954; 71376-205; 0078-0440; 0527-1914; 0527-4579; 16714-822; 43547-488; 61960-7000; 42858-077; 31722-953; 0378-8155; 51862-612; 0406-1810; 0591-3895; 16729-478; 63629-1904; 51634-0114; 67877-603; 0078-0370; 43598-441; 59116-3394; 0378-8156; 11014-0230; 60687-565; 43386-575; 42858-078; 72912-555; 0406-1144; 72865-126; 63629-1231; 65162-235; 0406-1820; 0406-0154; 0115-1741; 43598-440; 42858-076; 50458-587; 43386-931; 0378-8157; 40032-571; 60274-549; 24478-075; 0115-1740; 10702-101; 63629-1920; 43386-570; 0406-1335; 72865-127; 47781-418; 67877-615; 10147-0687; 70010-012; 62037-727; 65267-114; 0078-0424; 50458-588; 0115-1737; 42291-568; 10702-100; 72912-585; 42291-571; 0406-0127; 0078-0439; 11014-0081; 0093-5297; 57664-607; 63629-2463; 63629-1921; 0115-1739; 0527-4584; 0792-0101; 11014-0371; 42858-075; 24478-323; 62037-734; 60274-546; 13811-706; 51407-527; 65162-231; 71335-1219; 71376-202; 0406-1840; 43386-573; 63629-1903; 0527-3310; 68084-805; 70752-131; 63629-2460; 13811-707; 63629-2459; 16729-480; 0591-3902; 0115-1801; 62037-725; 0406-1860; 10702-164; 62175-310; 0527-4583; 11014-0319; 60274-542; 60687-554; 67877-617; 70010-015; 51991-611; 51407-528; 42858-079; 63629-2461; 70010-043; 65162-237; 63629-1172; 57664-606; 60274-547; 50268-547; 31722-926; 43602-178; 64980-223; 70010-016; 31722-927; 71376-204; 42291-569; 51927-3076; 67877-602; 63629-1923; 16714-821; 0093-5298; 31722-173; 0078-0372; 72912-525; 31722-174; 71335-0892; 64980-221; 67877-618; 0406-1142; 70752-132; 60687-532; 0406-1850; 57664-609; 57664-229; 43598-438; 51991-612; 47781-417; 72912-535; 0093-5348; 63629-1919; 60687-543; 72865-122; 0591-3873; 13107-380; 13107-381; 50458-586; 0406-8335; 72865-123; 0406-1830; 50268-545; 24478-321; 72865-134; 43386-574; 50268-529; 43547-486; 62175-313; 72865-124; 47781-415; 65267-115; 0527-3313; 71376-201; 57664-228; 31722-175; 16729-479; 51862-610; 38779-0851; 40032-570; 24478-324; 62037-726; 50268-528; 0078-0371; 24478-076; 71930-024; 60274-548; 11014-0083; 59116-3392; 0078-0441; 24478-074; 10702-163; 0093-5347; 71376-203; 59630-750; 0527-3311; 50268-546; 72912-570; 10702-102; 60274-949; 0527-1915; 67877-616; 0406-1571; 0115-1736; 0406-0136; 68084-823; 0115-1738; 0406-1146; 70010-014; 0093-5293; 62175-312; 63629-1902; 24478-322; 10147-0685; 0406-1473; 70010-013; 16714-823; 71930-025; 60274-948; 31722-952; 40032-572; 10147-0688; 0527-4582; 13811-710; 0093-5295; 72865-125; 0591-3891; 13107-382; 72865-133; 60274-946; 0115-1802; 51862-609; 43386-571; 65162-233; 42858-081; 0093-5292; 0406-2069; 47781-629; 59630-755; 72912-545; 11014-0082; 63629-1922; 43386-572; 60274-947; 0115-1800; 0406-1445; 31722-928; 63629-2462; 13811-709; 43602-177; 60274-942; 42291-570; 57664-608; 0406-0570; 68025-084; 63629-1176; 72865-135; 42858-080; 0378-8158; 0093-5296; 59116-3391; 17180-1724; 0093-5346; 50268-548; 13811-708; 70010-042; 62175-311; 51862-611; 43386-930; 31722-955; 63629-1924; 47781-631; 0591-3854; 49452-4682; 10147-0686; 0527-3312; 0527-4580; 27808-059; 64980-222; 59116-3390; 50458-585; 57664-230; 67509-001; 27808-058; 53834-502; 0591-3869; 72865-136; 43598-439; 0591-3862
Synonyms Methylphenidate | Metadate | Equasym | Methylin | Concerta | Phenidylate | Ritalin | Ritaline | Ritalin-SR | Ritalin SR | Tsentedrin | Centedrin | Daytrana | Methylphenidate Hydrochloride | Hydrochloride, Methylphenidate
Chemical Information
Molecular Formula C14H19NO2.ClH
CAS Registry Number 298-59-9
SMILES COC(=O)C(C1CCCCN1)C2=CC=CC=C2.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HepatotoxicityBeta-2 adrenergic receptorP07550T52522Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Heart rate increased13.14.04.002--Not Available
Hepatic function abnormal09.01.02.001--Not Available
Hypersensitivity10.01.03.003--
Hypomania19.16.02.001--Not Available
Insomnia17.15.03.002; 19.02.01.002--
Irritability19.04.02.013; 08.01.03.011--
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Leukopenia01.02.02.001--Not Available
Liver function test abnormal13.03.01.013--Not Available
Migraine24.03.05.003; 17.14.02.001--Not Available
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.003--Not Available
Neuroleptic malignant syndrome12.03.01.003; 08.05.01.005; 17.05.02.003; 15.05.04.015--Not Available
Obsessive-compulsive disorder19.06.05.002--Not Available
Palpitations02.01.02.003--
Peripheral coldness24.04.03.006; 08.01.09.010--Not Available
Psychomotor hyperactivity19.11.02.003; 17.01.02.011--Not Available
Pulse abnormal13.14.04.004--Not Available
Pulse pressure decreased13.14.04.008--Not Available
Pulse pressure increased13.14.04.007--Not Available
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Raynaud's phenomenon24.04.03.003--Not Available
Rhabdomyolysis15.05.05.002--
Somnolence17.02.04.006; 19.02.05.003--
Sudden death08.04.01.003; 02.03.04.013--
Tachycardia02.03.02.007--Not Available
Thrombocytopenia01.08.01.002--Not Available
Thrombocytopenic purpura23.06.01.007; 01.08.01.003--Not Available
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