Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Mesalamine
Drug ID BADD_D01397
Description An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease [A174022]. It is considered to be the active moiety of sulphasalazine. (From Martindale, The Extra Pharmacopoeia, 30th ed) Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent [A174019]. Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules [A174019]. In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.[A174019,A174022]
Indications and Usage Mesalazine is indicated for the induction of remission in patients with active or mild to moderate acute exacerbations of ulcerative colitis and for the maintenance of remission of ulcerative colitis [FDA Label], [L5101]. Prescribing information for mesalazine in the UK also indicates the medication for the maintenance of remission of Crohn's ileo-colitis [L5101].
Marketing Status approved
ATC Code A07EC02
DrugBank ID DB00244
KEGG ID D00377
MeSH ID D019804
PubChem ID 4075
TTD Drug ID D0C4YC
NDC Product Code 0023-5854; 49452-0450; 21922-045; 59762-0117; 62332-724; 68382-452; 68682-113; 54127-0945; 62331-064; 58914-501; 60687-650; 0037-0066; 67877-717; 68382-435; 0023-5801; 11014-0129; 0904-6832; 51927-1078; 57297-192; 57451-1141; 54092-100; 54092-189; 59651-397; 0037-0022; 60687-397; 63304-175; 0378-1375; 69918-560; 0781-7088; 12598-9155; 24528-0003; 49957-511; 59285-037; 63552-042; 42291-563; 51407-274; 63629-2397; 65649-103; 70710-1302; 42419-024; 49706-0882; 70966-0035; 45802-098; 50268-577; 63629-8678; 0527-3012; 70771-1513; 0591-2245; 12598-9151; 12598-9554; 47621-059; 54127-0947; 70600-006; 45802-929; 46708-724; 0023-5901; 54092-476; 60687-556; 62559-420; 63629-8679; 63629-8827; 64980-282; 68382-711; 70518-3239; 70710-1543; 70771-1110; 49964-0015; 54127-0950; 62350-0076; 62756-115; 63552-043; 16714-245; 42291-564; 50090-3002; 0023-5853; 0472-1915; 70771-1353; 70771-1625; 12598-5158; 12598-9553; 12651-582; 62331-060; 62512-0072; 31722-005; 45802-923; 54092-191; 59762-0118; 60687-408; 63304-089; 70748-214; 12598-9154; 59651-396; 62991-2705; 67454-001; 68743-476; 16714-830; 0093-5907; 43353-884; 60687-703; 70771-1071; 12598-5163; 49706-8821; 54127-0943; 0093-9224
UNII 4Q81I59GXC
Synonyms Mesalamine | Mesalazine | m-Aminosalicylic Acid | m Aminosalicylic Acid | 5-Aminosalicylic Acid | 5 Aminosalicylic Acid | meta-Aminosalicylic Acid | meta Aminosalicylic Acid | Asacol | Asacolon | Ascolitin | Canasa | Claversal | Fivasa | Salofalk | Lixacol | Mesalamine Hydrochloride | Hydrochloride, Mesalamine | Mesalamine Monosodium Salt | Monosodium Salt, Mesalamine | Mesasal | Novo-5 ASA | Novo 5 ASA | Pentasa | Rowasa | 5-Aminosalicylate | 5 Aminosalicylate
Chemical Information
Molecular Formula C7H7NO3
CAS Registry Number 89-57-6
SMILES C1=CC(=C(C=C1N)C(=O)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Unevaluable event08.01.03.0510.002854%Not Available
Hepatic enzyme abnormal13.03.04.026--Not Available
Cystitis noninfective20.03.02.001--
Bowel movement irregularity07.02.03.0030.000622%Not Available
Hypophagia19.09.01.004; 14.03.01.006; 07.01.06.0100.000274%Not Available
Lichenoid keratosis23.01.01.004--Not Available
Gastrointestinal inflammation07.08.03.0070.000183%Not Available
Chronic kidney disease20.01.03.017--
Vulvovaginal mycotic infection21.14.02.004; 11.03.05.004--Not Available
Bone marrow failure01.03.03.005--
Cytopenia01.03.03.0120.000183%Not Available
Tendon pain15.07.01.0090.000403%Not Available
Acute interstitial pneumonitis22.01.02.016--Not Available
Treatment failure08.06.01.0170.002305%Not Available
Liver injury12.01.17.012; 09.01.07.0220.000457%Not Available
Organising pneumonia22.01.02.0080.000823%Not Available
Oral disorder07.05.01.0050.000403%Not Available
Focal segmental glomerulosclerosis20.05.01.0030.000823%Not Available
Cholestatic liver injury09.01.07.0160.000183%Not Available
Anal pruritus07.03.03.002--Not Available
Anorectal discomfort07.03.03.003--Not Available
Oropharyngeal discomfort22.12.03.015; 07.05.05.008--Not Available
Oropharyngeal pain22.12.03.016; 07.05.05.0040.001262%
Acute kidney injury20.01.03.016--
Sperm concentration decreased13.20.04.008--Not Available
Drug-induced liver injury12.03.01.044; 09.01.07.0230.001006%Not Available
Granulomatosis with polyangiitis24.12.04.011; 22.01.01.015; 20.05.01.013; 10.02.02.0180.000274%Not Available
Lacrimal structural disorder06.06.04.013--Not Available
Drug reaction with eosinophilia and systemic symptoms12.03.01.064; 10.01.01.021; 23.03.05.0050.000366%Not Available
Candida infection11.03.03.021--
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