Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lomefloxacin hydrochloride
Drug ID BADD_D01310
Description Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well.
Indications and Usage For the treatment of bacterial infections of the respiratory tract (chronic bronchitis) and urinary tract, and as a pre-operative prophylactic to prevent urinary tract infection caused by: S.pneumoniae, H.influenzae, S.aureus, P.aeruginosa, E. cloacae, P. mirabilis, C. civersus, S. asprphyticus, E.coli, and K.pneumoniae.
Marketing Status Discontinued
ATC Code J01MA07; S01AE04
DrugBank ID DB00978
KEGG ID D00873
MeSH ID C053091
PubChem ID 68624
TTD Drug ID D02KOF
NDC Product Code Not Available
Synonyms lomefloxacin | lomenfloxacin | 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid | lomefloxacin hydrochloride | Maxaquin | Logiflox | Ocacin | Okacin | Okacyn | SC 4711 | SC-4711 | Décalogiflox | NY 198 | NY-198
Chemical Information
Molecular Formula C17H20ClF2N3O3
CAS Registry Number 98079-52-8
SMILES CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCNC(C3)C)F)C(=O)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Eosinophilia01.02.04.001--
Epididymitis21.09.02.001; 11.01.19.005--Not Available
Epistaxis24.07.01.005; 22.04.03.001--
Extrasystoles02.03.02.003--Not Available
Eye pain06.08.03.002--
Face oedema08.01.07.003; 23.04.01.004; 10.01.05.002--
Fatigue08.01.01.002--
Fibrinolysis increased13.01.02.027--Not Available
Flatulence07.01.04.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Fungal infection11.03.05.001--Not Available
Gamma-glutamyltransferase increased13.03.01.011--
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gout15.01.06.001; 14.09.01.001--Not Available
Haematuria24.07.01.047; 20.02.01.006--
Haemoglobin decreased13.01.05.003--Not Available
Haemolytic anaemia01.06.03.002--Not Available
Hallucination19.10.02.002--
Headache17.14.01.001--
Hepatic function abnormal09.01.02.001--Not Available
Hepatitis09.01.07.004--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperkinesia17.01.02.008--Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypertonia17.05.02.001; 15.05.04.007--Not Available
Hypoglycaemia14.06.03.001; 05.06.03.001--
Hypotension24.06.03.002--
Increased appetite14.03.01.003; 08.01.09.027--Not Available
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