Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lithium carbonate
Drug ID BADD_D01303
Description Lithium has been used to treat manic episodes since the 19th century[A176642]. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label].
Indications and Usage Lithium is used as a mood stabilizer, and is used for treatment of depression and mania. It is often used in bipolar disorder treatment.
Marketing Status Prescription; Discontinued
ATC Code N05AN01
DrugBank ID DB14509
KEGG ID D00801
MeSH ID D016651
PubChem ID 11125
TTD Drug ID D04UUH
NDC Product Code 72789-173; 68462-222; 71610-557; 0220-3128; 0054-2531; 31722-546; 68462-224; 0054-0021; 71335-0120; 64117-256; 50090-1470; 46708-303; 70518-0437; 51079-180; 0054-8527; 0054-8526; 0054-2527; 62559-280; 0054-0020; 50090-2799; 0378-1450; 68084-655; 51079-142; 0378-1300; 68462-221; 0054-4527; 70518-0904; 50090-2959; 46708-304; 68084-640; 71335-1067; 0220-3129; 63629-7730; 66039-947; 58118-0545; 70518-0668; 62332-013; 72789-174; 50090-2754; 73309-248; 63629-1916; 64980-278; 82388-001; 0054-2526; 70518-2312; 63629-8282; 63629-1917; 55154-4920; 68428-481; 62332-014; 62756-430; 0054-8528; 70518-0608; 64980-205; 42291-496; 62332-015; 70518-2345; 68462-220; 50090-3918; 23155-763; 68788-7716; 0220-3131; 63187-304; 70518-1753; 71335-1006; 46708-305; 46708-148; 70518-2086; 62332-148; 31722-544; 63629-7903; 68462-223; 72789-171; 72789-172; 50090-3917; 0615-8302; 70518-2699; 0054-8531; 39345-5104; 43063-901; 70518-1434; 31722-545
Synonyms Lithium Carbonate | Carbonate, Lithium | Dilithium Carbonate | Carbonate, Dilithium | Lithane | Lithium Bicarbonate | Bicarbonate, Lithium | Lithobid | Lithonate | CP-15,467-61 | CP 15,467 61 | CP15,46761 | Micalith | NSC-16895 | NSC 16895 | NSC16895 | Priadel | Quilinorm-retard | Quilinorm retard | Quilinormretard | Eskalith | Lithotabs
Chemical Information
Molecular Formula CLi2O3
CAS Registry Number 554-13-2
SMILES [Li+].[Li+].C(=O)([O-])[O-]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Nephrogenic diabetes insipidusVasopressin V2 receptorP48044Not AvailableNot Available
Renal aplasiaVasopressin V2 receptorP48044Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dystonia17.01.03.001--Not Available
Electrocardiogram abnormal13.14.05.0010.000818%Not Available
Electrocardiogram normal13.14.05.022--Not Available
Electrocardiogram QT prolonged13.14.05.0040.004497%
Electrocardiogram ST segment elevation13.14.05.0250.001227%Not Available
Electrocardiogram T wave inversion13.14.05.007--Not Available
Electroencephalogram abnormal13.07.03.0010.001227%Not Available
Electrolyte imbalance14.05.01.0020.000818%Not Available
Encephalopathy17.13.02.0010.003680%
Enuresis20.02.02.003; 19.07.04.0010.000818%Not Available
Epilepsy17.12.03.002--Not Available
Erythema multiforme23.03.01.003; 10.01.03.0150.000818%
Euphoric mood19.04.02.0060.000818%
Exophthalmos06.09.04.001; 05.02.02.002--Not Available
Extrapyramidal disorder17.01.02.0070.002044%
Fatigue08.01.01.002--
Feeling abnormal08.01.09.0140.001635%Not Available
Flatulence07.01.04.002--
Folliculitis23.09.04.007; 11.01.12.018--
Gait disturbance17.02.05.016; 08.01.02.0020.004088%
Galactorrhoea21.05.02.002; 05.03.04.0020.000818%Not Available
Gastritis07.08.02.001--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Generalised tonic-clonic seizure17.12.01.0020.000818%Not Available
Glomerular filtration rate decreased13.13.01.0090.000818%Not Available
Glycosuria20.02.01.005--
Goitre14.11.01.008; 05.02.01.0010.002453%Not Available
Hair texture abnormal23.02.06.004--
Hallucination19.10.02.002--
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