Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ketoprofen
Drug ID BADD_D01231
Description Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
Indications and Usage For symptomatic treatment of acute and chronic rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, primary dysmenorrhea and mild to moderate pain associated with musculotendinous trauma (sprains and strains), postoperative (including dental surgery) or postpartum pain.
Marketing Status Prescription; Discontinued
ATC Code M01AE03; M02AA10
DrugBank ID DB01009
KEGG ID D00132
MeSH ID D007660
PubChem ID 3825
TTD Drug ID D0W9WF
NDC Product Code 49452-3917; 68981-031; 82348-102; 0276-0504; 12660-0006; 69336-127; 12854-516; 43235-0010; 63275-9996; 51927-0057; 76465-0001; 51927-0025; 51552-0307; 63187-018; 38779-0078; 51927-0231; 0395-8056; 45865-485; 38779-3039; 49452-3924; 0378-8200; 79572-019; 51604-0011
Synonyms Ketoprofen | Benzoylhydratropic Acid | 2-(3-Benzoylphenyl)propionic Acid | Profenid | Alrheumum | Orudis | 19,583 RP | RP, 19,583 | RP-19583 | RP 19583 | RP19583 | Alrheumat
Chemical Information
Molecular Formula C16H14O3
CAS Registry Number 22071-15-4
SMILES CC(C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Gastrointestinal toxicityTumor necrosis factorP01375T2017811991627; 11131303; 11930903; 11230998
Gastrointestinal toxicityGlutathione reductase, mitochondrialP00390T3080311991627; 11131303; 11930903; 11230998
Toxic dilatation of intestineTumor necrosis factorP01375T2017811991627; 11131303; 11930903; 11230998
Toxic dilatation of intestineGlutathione reductase, mitochondrialP00390T3080311991627; 11131303; 11930903; 11230998
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gynaecomastia21.05.04.003; 05.05.02.003--
Haemarthrosis24.07.01.046; 15.01.01.004; 12.04.03.0010.008278%Not Available
Haematemesis24.07.02.011; 07.12.02.0020.037250%Not Available
Haematochezia24.07.02.012; 07.12.02.0030.008278%Not Available
Haematuria24.07.01.047; 20.02.01.006--
Haemolysis01.06.04.002--
Haemolytic uraemic syndrome20.01.03.011; 01.06.02.0010.016556%
Haemoptysis24.07.01.006; 22.02.03.004; 02.01.02.006--Not Available
Hallucination19.10.02.002--
Headache17.14.01.001--
Hepatic function abnormal09.01.02.001--Not Available
Hepatitis09.01.07.004--Not Available
Hepatitis acute09.01.07.0050.008278%Not Available
Hepatitis cholestatic09.01.01.0020.008278%Not Available
Hepatocellular injury09.01.07.0080.045528%Not Available
Hyperaemia24.03.02.0020.008278%Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.0030.074501%
Hypertension24.08.02.001--
Hypocoagulable state01.01.02.004--Not Available
Hypoglycaemia14.06.03.001; 05.06.03.0010.012417%
Hypokalaemia14.05.03.0020.016556%
Hyponatraemia14.05.04.0020.008278%
Hypotension24.06.03.0020.028973%
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Infection11.01.08.0020.024834%Not Available
Insomnia19.02.01.002; 17.15.03.002--
Intestinal ulcer07.04.06.003--Not Available
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.0040.008278%Not Available
Laryngeal oedema23.04.01.005; 22.04.02.001; 10.01.05.003--
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