Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Itraconazole
Drug ID BADD_D01217
Description One of the triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis.
Indications and Usage For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.
Marketing Status Prescription; Discontinued
ATC Code J02AC02
DrugBank ID DB01167
KEGG ID D00350
MeSH ID D017964
PubChem ID 55283
TTD Drug ID D0V4IB
NDC Product Code 12578-299; 50268-450; 53069-0450; 58032-0110; 0378-5100; 68382-697; 66577-044; 63629-8168; 60687-299; 10147-0150; 70518-3264; 50458-290; 62991-3078; 10147-1700; 71747-002; 65162-630; 67835-5043; 16729-271; 10695-064; 22568-1108; 67877-454; 31722-006; 65162-087; 46708-204; 38779-2759; 62332-204; 60592-318; 72761-019; 70771-1208; 49884-239; 70518-2872; 66039-815; 17511-114; 50458-295; 59349-0012; 13668-463; 0395-8113; 71052-301; 50546-462; 16714-743; 51552-0920; 65015-624; 51862-462
Synonyms Itraconazole | R-51211 | R 51211 | R51211 | Sporanox | Orungal
Chemical Information
Molecular Formula C35H38Cl2N8O4
CAS Registry Number 84625-61-6
SMILES CCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5COC(O5)(CN6C=NC=N6)C 7=C(C=C(C=C7)Cl)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Generalised oedema08.01.07.004; 14.05.06.007--
Gingivitis11.01.04.013; 07.09.03.003--
Gynaecomastia21.05.04.003; 05.05.02.003--
Haematuria24.07.01.047; 20.02.01.0060.023206%
Haemoglobin decreased13.01.05.003--Not Available
Haemoptysis02.01.02.006; 24.07.01.006; 22.02.03.0040.007264%Not Available
Haemorrhage intracranial24.07.04.003; 17.08.01.0080.002421%
Haemorrhoids07.15.03.001; 24.10.02.0020.009282%
Hallucination19.10.02.0020.032488%
Headache17.14.01.0010.088182%
Hepatic failure09.01.03.0020.037129%
Hepatic function abnormal09.01.02.0010.055694%Not Available
Hepatic steatosis14.08.04.005; 09.01.07.0030.009282%Not Available
Hepatitis09.01.07.0040.018565%Not Available
Hepatitis cholestatic09.01.01.0020.009282%Not Available
Hepatocellular injury09.01.07.0080.023206%Not Available
Hepatotoxicity12.03.01.008; 09.01.07.0090.041771%Not Available
Herpes zoster11.05.02.003; 23.09.03.002--
Histoplasmosis11.03.06.0010.012107%Not Available
Hyperbilirubinaemia14.11.01.010; 09.01.01.003; 01.06.04.0030.041771%Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperkalaemia14.05.03.001--
Hyperpyrexia08.05.02.0020.009282%Not Available
Hypersensitivity10.01.03.0030.041771%
Hypersensitivity vasculitis24.05.02.012; 23.06.02.005; 10.02.02.017; 01.01.04.008--Not Available
Hypertension24.08.02.0010.041771%
Hypertriglyceridaemia14.08.02.001--
Hyperuricaemia14.09.01.0030.009282%
Hypoaesthesia17.02.06.023--Not Available
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