Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Isoniazid
Drug ID BADD_D01204
Description Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.
Indications and Usage For the treatment of all forms of tuberculosis in which organisms are susceptible.
Marketing Status Prescription; Discontinued
ATC Code J04AC01
DrugBank ID DB00951
KEGG ID D00346
MeSH ID D007538
PubChem ID 3767
TTD Drug ID D09XQF
NDC Product Code 71610-108; 50090-1490; 60687-553; 43063-463; 71052-611; 50090-0370; 12785-0002; 50090-0410; 0527-1109; 53002-2920; 71335-0275; 68788-9405; 71610-395; 0555-0071; 46287-009; 63187-978; 12785-0003; 66639-914; 0781-3056; 0555-0066; 70518-0096; 70518-2576; 51079-083
Synonyms Isoniazid | Isonicotinic Acid Hydrazide | Hydrazide, Isonicotinic Acid | Phthivazide | Phthivazid | Isonicotinic Acid Vanillylidenehydrazide | Acid Vanillylidenehydrazide, Isonicotinic | Vanillylidenehydrazide, Isonicotinic Acid | Ftivazide | Tubazide | Isonex
Chemical Information
Molecular Formula C6H7N3O
CAS Registry Number 54-85-3
SMILES C1=CN=CC=C1C(=O)NN
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HepatotoxicityAlbuminP02770Not Available26004706
HepatotoxicityCatalaseP04762Not Available26004706
HepatotoxicityN-alpha-acetyltransferase 20P61599Not Available3691615; 9922980
HepatotoxicityOmega-amidase NIT2Q9JHW2Not Available26004706
HepatotoxicityGlutathione peroxidase 1P04041Not Available26004706
HepatotoxicityAlanine aminotransferase 1P24298Not Available4000989; 707874; 110184
HepatotoxicityN-alpha-acetyltransferase 20P61599Not AvailableNot Available
Systemic lupus erythematosusN-alpha-acetyltransferase 20P61599Not AvailableNot Available
Systemic lupus erythematosusN-alpha-acetyltransferase 20P61599Not Available3691615; 9922980
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Oliguria20.01.03.0040.019111%Not Available
Optic neuritis17.04.05.001; 10.04.10.002; 06.04.08.0020.012741%Not Available
Oral pain07.05.03.002--
Oxygen saturation decreased13.02.01.0040.012741%Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Pallor08.01.03.032; 24.03.04.001; 23.03.03.0310.025481%Not Available
Palpitations02.01.02.003--
Pancreatitis07.18.01.0010.019111%
Pancreatitis acute07.18.01.0020.127405%Not Available
Pancytopenia01.03.03.0030.031851%Not Available
Paraesthesia17.02.06.005--
Paralysis17.01.04.0040.019111%Not Available
Pemphigoid23.03.01.004; 10.04.02.0020.012741%Not Available
Pericardial effusion02.06.01.0020.038222%
Peritoneal haemorrhage24.07.02.016; 07.07.02.0010.003324%Not Available
Petechiae24.07.06.004; 23.06.01.003; 01.01.03.0020.012741%Not Available
Platelet count decreased13.01.04.0010.057332%
Pleural effusion22.05.02.0020.031851%
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pneumonia aspiration22.01.01.0050.004985%Not Available
Pneumonitis22.01.01.0060.038222%
Pneumothorax22.05.02.0030.012741%
Premature baby18.04.02.0010.031851%Not Available
Premature delivery18.07.01.0060.012741%
Presyncope24.06.02.010; 17.02.05.009; 02.01.02.0070.012741%
Proteinuria20.02.01.0110.038222%
Prothrombin time prolonged13.01.02.0120.025481%Not Available
Pruritus23.03.12.001--
Pulmonary alveolar haemorrhage24.07.01.015; 22.01.02.0050.003324%Not Available
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