Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Immunoglobulin (human)
Drug ID BADD_D01144
Description Intravenous immunoglobulin (IVIg) is a mixture of IgG1 and other antibodies derived from healthy human plasma via Cohn fractionation. The purification process includes cold alcohol fractionation, polyethylene glycol precipitation, and ion exchange chromatography. IVIg contains the same distribution of IgG antibody subclasses as is found in the general human population. IgG subclasses are fully represented in the following proportions: 70.3% IgG1, 24.7% IgG2, 3.1% IgG3, and 1.9% IgG4. IVIg is used in the treatment of immunodeficiencies, as well as autoimmune and inflammatory disorders.
Indications and Usage Not Available
Marketing Status Not Available
ATC Code J06BA01
DrugBank ID DB00028
KEGG ID D06458
MeSH ID D007136
PubChem ID Not Available
TTD Drug ID Not Available
NDC Product Code 44206-436; 44206-439; 44206-438; 44206-437; 44206-454; 44206-457; 64208-8234; 44206-458; 44206-455; 44206-452; 69800-0250; 44206-451; 44206-456; 64208-8235
Synonyms Immunoglobulins | Globulins, Immune | Immunoglobulin | Immune Globulin | Globulin, Immune | Immune Globulins
Chemical Information
Molecular Formula Not Available
CAS Registry Number 308067-58-5
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Acute respiratory distress syndrome22.01.03.001--
Apnoea22.02.01.001--
Arthralgia15.01.02.001--
Back pain15.03.04.005--
Blood pressure abnormal13.14.03.001--Not Available
Bronchospasm10.01.03.012; 22.03.01.004--
Cardiac arrest02.03.04.001--
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Chills15.05.03.016; 08.01.09.001--
Circulatory collapse24.06.02.001--Not Available
Coma17.02.09.001--Not Available
Coombs direct test13.01.01.006--Not Available
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.002--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dizziness02.01.02.004; 24.06.02.007; 17.02.05.003--
Dyspnoea22.02.01.004; 02.01.03.002--
Erythema multiforme23.03.01.003; 10.01.03.015--
Fatigue08.01.01.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Haemolysis01.06.04.002--
Headache17.14.01.001--
Hepatic function abnormal09.01.02.001--Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypotension24.06.03.002--
Hypoxia22.02.02.003--
Insomnia17.15.03.002; 19.02.01.002--
Leukopenia01.02.02.001--Not Available
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