Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hydroxyurea
Drug ID BADD_D01110
Description An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
Indications and Usage For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Marketing Status Prescription; Discontinued
ATC Code L01XX05
DrugBank ID DB01005
KEGG ID D00341
MeSH ID D006918
PubChem ID 3657
TTD Drug ID D07CWD
NDC Product Code 70518-0916; 0904-6939; 51927-0072; 49452-3650; 0003-6337; 60429-265; 55154-7143; 0003-0830; 10135-702; 71770-120; 49884-724; 55512-0003; 68084-284; 51552-0851; 17337-0022; 0003-6336; 35369-0006; 0555-0882; 0003-6335; 42291-321; 51927-2655; 71052-323; 69315-164; 17337-0023; 71770-105
Synonyms Hydroxyurea | Hydroxycarbamid | Oncocarbide | Hydrea
Chemical Information
Molecular Formula CH4N2O2
CAS Registry Number 127-07-1
SMILES C(=O)(N)NO
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Chronic myeloid leukaemiaTyrosine-protein kinase ABL1P00519T6350511841409; 11273186; 9516377; 15510207
HepatomegalyTyrosine-protein kinase ABL1P00519T6350511841409; 11273186; 9516377; 15510207
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Drug abuse19.07.02.010--Not Available
Drug dependence19.07.02.0090.000139%Not Available
Drug hypersensitivity10.01.01.001--Not Available
Dry skin23.03.03.001--
Dysarthria19.19.03.001; 17.02.08.0010.000533%
Dyspepsia07.01.02.0010.000799%
Dysphagia07.01.06.0030.001459%
Dysphonia22.02.05.005; 19.19.03.002; 17.02.08.0040.000533%
Dyspnoea22.02.01.004; 02.01.03.0020.005595%
Dyspnoea exertional22.02.01.005; 02.01.03.0030.000533%Not Available
Dysuria20.02.02.002--
Electrocardiogram QT prolonged13.14.05.004--
Epistaxis24.07.01.005; 22.04.03.0010.001598%
Epstein-Barr virus infection11.05.10.0040.000799%
Erythema23.03.06.0010.001598%Not Available
Erythema infectiosum23.03.08.007; 11.05.15.002--Not Available
Erythroleukaemia16.01.05.002; 01.10.05.0020.000139%Not Available
Essential thrombocythaemia16.21.03.004; 01.13.03.0030.000278%Not Available
Face oedema10.01.05.002; 08.01.07.003; 23.04.01.004--
Facial paralysis17.04.03.0080.000533%Not Available
Fatigue08.01.01.002--
Febrile neutropenia08.05.02.004; 01.02.03.0020.001865%
Feeling abnormal08.01.09.014--Not Available
Femur fracture15.08.03.003; 12.04.01.003--Not Available
Fibrosis08.03.01.0010.000533%Not Available
Folate deficiency14.12.02.006--Not Available
Fracture12.04.02.001; 15.08.02.0010.003463%
Gamma-glutamyltransferase increased13.03.01.0110.000799%
Gangrene11.02.01.003; 24.04.05.003; 23.06.06.001--Not Available
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