Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Halothane
Drug ID BADD_D01057
Description A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)
Indications and Usage For the induction and maintenance of general anesthesia
Marketing Status Discontinued
ATC Code N01AB01
DrugBank ID DB01159
KEGG ID D00542
MeSH ID D006221
PubChem ID 3562
TTD Drug ID D0D8VE
NDC Product Code Not Available
Synonyms Halothane | 1,1,1-Trifluoro-2-Chloro-2-Bromoethane | Ftorotan | Narcotan | Fluothane
Chemical Information
Molecular Formula F3CCHBrCl
CAS Registry Number 151-67-7
SMILES C(C(F)(F)F)(Cl)Br
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionAlanine aminotransferase 1P24298Not Available6613602; 6141900; 3964517; 12655034
Adverse drug reactionAlanine aminotransferase 1P24298Not Available3237593; 2840650; 3105540; 1709034; 3183968; 8638846; 3564016; 7899258; 3187193; 3964517; 12074095
Adverse drug reactionAlanine aminotransferase 1P24298Not Available6868087; 6312740; 484893; 3979956; 7258721; 3354886; 3188577; 2840650; 6881584
Breast hyperplasiaAlanine aminotransferase 1P24298Not Available3237593; 2840650; 3105540; 1709034; 3183968; 8638846; 3564016; 7899258; 3187193; 3964517; 12074095
Breast hyperplasiaAlanine aminotransferase 1P24298Not Available6868087; 6312740; 484893; 3979956; 7258721; 3354886; 3188577; 2840650; 6881584
Breast hyperplasiaAlanine aminotransferase 1P24298Not Available6613602; 6141900; 3964517; 12655034
Hepatic necrosisAlanine aminotransferase 1P24298Not Available6613602; 6141900; 3964517; 12655034
Hepatic necrosisAlanine aminotransferase 1P24298Not Available3237593; 2840650; 3105540; 1709034; 3183968; 8638846; 3564016; 7899258; 3187193; 3964517; 12074095
Hepatic necrosisAlanine aminotransferase 1P24298Not Available6868087; 6312740; 484893; 3979956; 7258721; 3354886; 3188577; 2840650; 6881584
Hepatic steatosisAlanine aminotransferase 1P24298Not Available3237593; 2840650; 3105540; 1709034; 3183968; 8638846; 3564016; 7899258; 3187193; 3964517; 12074095
Hepatic steatosisAlanine aminotransferase 1P24298Not Available6868087; 6312740; 484893; 3979956; 7258721; 3354886; 3188577; 2840650; 6881584
Hepatic steatosisAlanine aminotransferase 1P24298Not Available6613602; 6141900; 3964517; 12655034
HepatotoxicityAlanine aminotransferase 1P24298Not Available3237593; 2840650; 3105540; 1709034; 3183968; 8638846; 3564016; 7899258; 3187193; 3964517; 12074095
HepatotoxicityAlanine aminotransferase 1P24298Not Available6868087; 6312740; 484893; 3979956; 7258721; 3354886; 3188577; 2840650; 6881584
HepatotoxicityCytochrome P450 2A6P11509T064559103523; 8886607; 8214760
HepatotoxicityAlanine aminotransferase 1P24298Not Available6613602; 6141900; 3964517; 12655034
HepatotoxicitySorbitol dehydrogenaseQ00796T594456868087; 6312740; 484893; 3979956; 7258721; 3354886; 3188577; 2840650; 6881584
HepatotoxicityCytochrome P450 2E1P05181Not Available9103523; 8886607; 8214760
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Arrhythmia02.03.02.001--Not Available
Cardiac arrest02.03.04.001--
Chills08.01.09.001; 15.05.03.016--
Hepatic necrosis09.01.07.002--
Hyperpyrexia08.05.02.002--Not Available
Hypotension24.06.03.002--
Nausea07.01.07.001--
Respiratory arrest22.02.01.009--Not Available
Vomiting07.01.07.003--
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