Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Guanfacine
Drug ID BADD_D01046
Description Guanfacine, or BS 100-141,[A189838,A189841] is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension[L11274] but is now indicated as an extended release tablet for the treatment of ADHD.[L11277] Guanfacine was first described in the literature in 1974.[A189841] Guanfacine was granted FDA approval on 27 October 1986.[L11274]
Indications and Usage For use alone or in combination with other classes of antihypertensive agents in the management of hypertension. Has also been used for the treatment of attention deficit hyperactivity disorder (ADHD) in pediatric patients.
Marketing Status Prescription; Discontinued
ATC Code C02AC02
DrugBank ID DB01018
KEGG ID D08031
MeSH ID D016316
PubChem ID 3519
TTD Drug ID Not Available
NDC Product Code 63304-927; 0591-0453; 63629-8203; 50090-4119; 70518-2771; 63304-924; 42291-326; 54092-519; 60429-961; 70518-1371; 0591-0444; 63304-925; 70518-0793; 54092-520; 63187-302; 60505-3927; 60429-960; 24979-536; 60429-963; 24658-731; 54092-517; 71205-945; 54092-515; 60429-962; 42806-048; 16714-193; 16714-190; 63629-1105; 42291-324; 42806-296; 24658-730; 63629-8161; 0228-2850; 42291-327; 24979-538; 16714-192; 63304-926; 0228-2853; 60505-3930; 16714-191; 60505-3928; 68094-019; 0228-2855; 50268-374; 24979-534; 65162-711; 0904-7140; 42291-325; 65162-713; 60505-3929; 71205-946; 70518-1369; 63629-7138; 24979-533; 71205-947; 54092-513; 0228-2851; 71205-944
Synonyms Guanfacine | Tenex | Guanfacine Hydrochloride | Hydrochloride, Guanfacine | Guanfacine Monohydrochloride | Monohydrochloride, Guanfacine | Lon798 | BS-100-141 | BS 100 141 | BS100141 | Estulic
Chemical Information
Molecular Formula C9H9Cl2N3O
CAS Registry Number 29110-47-2
SMILES C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Feeling hot08.01.09.0090.001049%Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.0250.001049%
Gastrointestinal pain07.01.05.005--
Haematoma24.07.01.0010.000699%
Hallucination19.10.02.0020.002448%
Hallucination, auditory19.10.02.0030.000699%Not Available
Headache17.14.01.0010.003497%
Heart rate decreased13.14.04.0010.001049%Not Available
Heart rate increased13.14.04.0020.002098%Not Available
Hyperhidrosis23.02.03.004; 08.01.03.0280.001049%
Hypersensitivity10.01.03.0030.001049%
Hypersomnia19.02.05.001; 17.15.01.0010.001049%
Hypertension24.08.02.0010.003147%
Hypoaesthesia17.02.06.0230.000699%Not Available
Hypokinesia17.01.02.009--Not Available
Hypotension24.06.03.0020.008043%
Hypothermia12.05.03.001; 08.05.01.0030.000699%
Immune system disorder10.02.01.001--Not Available
Increased appetite08.01.09.027; 14.03.01.0030.000699%Not Available
Initial insomnia17.15.03.005; 19.02.01.005--Not Available
Insomnia19.02.01.002; 17.15.03.0020.003497%
Intentional self-injury19.12.01.002; 12.01.08.0360.001399%Not Available
Iritis10.02.01.022; 06.04.03.002--Not Available
Irritability19.04.02.013; 08.01.03.0110.002448%
Lethargy08.01.01.008; 19.04.04.004; 17.02.04.0030.001748%
Libido decreased21.03.02.005; 19.08.03.001--
Liver function test abnormal13.03.01.013--Not Available
Loss of consciousness17.02.04.0040.005595%Not Available
Loss of libido19.08.03.003--Not Available
Malaise08.01.01.0030.001748%
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