Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fluphenazine hydrochloride
Drug ID BADD_D00937
Description A phenothiazine used in the treatment of psychoses. Its properties and uses are generally similar to those of chlorpromazine.
Indications and Usage For management of manifestations of psychotic disorders.
Marketing Status Discontinued; Prescription
ATC Code N05AB02
DrugBank ID DB00623
KEGG ID D00791
MeSH ID D005476
PubChem ID 67356
TTD Drug ID D0P5SA
NDC Product Code 0121-0653; 50090-5758; 10135-726; 16714-002; 69238-1680; 70710-1489; 0904-7157; 70518-3095; 16714-675; 0904-7159; 51407-458; 0527-1789; 16714-004; 10135-728; 70771-1582; 70954-275; 10135-725; 70710-1488; 0904-7160; 70518-3098; 0904-7158; 68084-950; 16714-005; 10135-727; 70771-1584; 0527-1788; 43598-036; 16714-674; 42291-437; 42291-436; 70954-274; 70518-3008; 68084-846; 70954-276; 43598-035; 70771-1581; 70518-1496; 69238-1678; 16714-003; 42291-438; 50268-369; 51407-461; 46708-937; 70710-1491; 43598-034; 68022-7063; 90096-122; 0527-1791; 70954-273; 42291-435; 16714-673; 0527-1790; 69766-068; 70710-1490; 69238-1681; 63323-281; 90096-124; 0121-0654; 51407-459; 90096-121; 51407-460; 70771-1583; 16714-672; 70518-3003; 48954-468; 69238-1679; 17856-0654; 90096-123; 46204-0002; 76055-0044; 50090-4740; 70518-0318; 43598-037
Synonyms Fluphenazine | Flufenazin | Fluphenazine Hydrochloride | Hydrochloride, Fluphenazine | Lyogen | Prolixin
Chemical Information
Molecular Formula C22H28Cl2F3N3OS
CAS Registry Number 146-56-5
SMILES C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO.Cl.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Tardive dyskinesiaD(2) dopamine receptorP14416T67162Not Available
Tardive dyskinesiaD(3) dopamine receptorP35462T02551Not Available
Tardive dyskinesiaD(4) dopamine receptorP21917T24983Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Akathisia19.06.02.006; 17.01.02.002--
Alcohol intolerance14.02.01.001--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Blood creatine phosphokinase increased13.04.01.001--
Blood pressure fluctuation24.06.01.002--Not Available
Cephalin flocculation13.09.01.018--Not Available
Constipation07.02.02.001--
Corneal opacity06.06.03.005--Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Dry mouth07.06.01.002--
Dyskinesia17.01.02.006--
Dystonia17.01.03.001--Not Available
Eczema23.03.04.006--
Eosinophilia01.02.04.001--
Erythema23.03.06.001--Not Available
Glaucoma06.03.01.002--
Gynaecomastia21.05.04.003; 05.05.02.003--
Headache17.14.01.001--
Hepatic function abnormal09.01.02.001--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperreflexia17.02.01.002--Not Available
Hypertension24.08.02.001--
Hypotension24.06.03.002--
Ileus paralytic07.02.05.001--Not Available
Laryngeal oedema23.04.01.005; 22.04.02.001; 10.01.05.003--
Leukocytosis01.02.01.002--
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