Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Flumazenil
Drug ID BADD_D00919
Description Fumazenil is an imidazobenzodiazepine derivative and a potent benzodiazepine receptor antagonist that competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex, thereby reversing the effects of benzodiazepine on the central nervous system.
Indications and Usage For the complete or partial reversal of the sedative effects of benzodiazepines in cases where general anesthesia has been induced and/or maintained with benzodiazepines, and where sedation has been produced with benzodiazepines for diagnostic and therapeutic procedures. Also for the management of benzodiazepine overdose as an adjunct for appropriate supportive and symptomatic measures.
Marketing Status Prescription; Discontinued
ATC Code V03AB25
DrugBank ID DB01205
KEGG ID D00697
MeSH ID D005442
PubChem ID 3373
TTD Drug ID D0D5GD
NDC Product Code 0404-9859; 65129-2026; 36000-149; 36000-148; 71872-7008; 0143-9784; 0143-9683; 52584-089; 50090-1337; 14778-0101; 51662-1254; 51916-311; 0143-9783; 0404-9860; 58175-0365; 71872-7038; 0143-9684; 52584-088; 63323-424; 51662-1579; 71872-7206; 51662-1253
Synonyms Flumazenil | Flumazepil | Romazicon | Lanexat | Ro 15-1788 | Ro 15 1788 | Ro 151788 | Anexate
Chemical Information
Molecular Formula C15H14FN3O3
CAS Registry Number 78755-81-4
SMILES CCOC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CC(=C3)F)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Drug withdrawal syndrome19.07.02.011; 08.06.02.004--Not Available
Dry mouth07.06.01.002--
Dysphonia22.02.05.005; 19.19.03.002; 17.02.08.004--
Dysphoria19.04.02.004--Not Available
Dyspnoea22.02.01.004; 02.01.03.002--
Epilepsy17.12.03.002--Not Available
Erythema23.03.06.001--Not Available
Euphoric mood19.04.02.006--
Fatigue08.01.01.002--
Fear19.06.03.001--Not Available
Feeling abnormal08.01.09.014--Not Available
Feeling cold08.01.09.008--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Hallucination19.10.02.002--
Headache17.14.01.001--
Hiccups22.02.04.002; 07.01.06.009--
Hyperacusis17.04.03.003; 04.02.02.001--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hyperventilation22.02.01.006; 19.01.02.004--Not Available
Hypoaesthesia17.02.06.023--Not Available
Hypopnoea22.02.01.021--Not Available
Hypotension24.06.03.002--
Injection site pain12.07.03.011; 08.02.03.010--Not Available
Injection site reaction12.07.03.015; 08.02.03.014--
Insomnia17.15.03.002; 19.02.01.002--
Lacrimation increased06.08.02.004--
Malaise08.01.01.003--
Menopausal symptoms21.02.02.002--Not Available
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