Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fludarabine
Drug ID BADD_D00914
Description Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara.
Indications and Usage For the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen
Marketing Status Not Available
ATC Code L01BB05
DrugBank ID DB01073
KEGG ID D07966
MeSH ID C024352
PubChem ID 657237
TTD Drug ID D0F2XQ
NDC Product Code Not Available
Synonyms fludarabine | 9H-purin-6-amine, 9-beta-D-arabinofuranosyl-2-fluoro- | F-ara-A | 2-fluoroadenine arabinoside | 9-beta-D-arabinofuranosyl-2-fluoroadenine
Chemical Information
Molecular Formula C10H12FN5O4
CAS Registry Number 21679-14-1
SMILES C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)CO)O)O)F)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Disorientation19.13.01.002; 17.02.05.0150.000533%Not Available
Drug eruption23.03.05.001; 10.01.01.005; 08.01.06.0150.000533%Not Available
Dyspepsia07.01.02.001--
Dysphagia07.01.06.003--
Dyspnoea22.02.01.004; 02.01.03.002--
Dysuria20.02.02.002--
Encephalitis17.06.05.001; 11.01.03.0080.000533%
Encephalopathy17.13.02.0010.000208%
Epilepsy17.12.03.0020.000533%Not Available
Epistaxis24.07.01.005; 22.04.03.0010.000799%
Erythema multiforme23.03.01.003; 10.01.03.015--
Fatigue08.01.01.002--
Febrile neutropenia08.05.02.004; 01.02.03.0020.004529%
Feeling abnormal08.01.09.014--Not Available
Fibrosis08.03.01.001--Not Available
Flank pain20.02.03.006; 15.03.04.003; 08.01.08.007--
Gait disturbance17.02.05.016; 08.01.02.002--
Gastroenteritis11.01.07.004; 07.19.03.0010.000533%Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal pain07.01.05.005--
Graft versus host disease12.02.09.001; 10.02.01.0270.000764%Not Available
Haematuria24.07.01.047; 20.02.01.006--
Haemoglobin13.01.05.018--Not Available
Haemoglobin decreased13.01.05.003--Not Available
Haemolytic anaemia01.06.03.0020.001598%Not Available
Haemoptysis22.02.03.004; 02.01.02.006; 24.07.01.006--Not Available
Hallucination19.10.02.002--
Headache17.14.01.001--
Hepatic failure09.01.03.0020.000278%
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