Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Epoprostenol
Drug ID BADD_D00788
Description A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
Indications and Usage For the long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy.
Marketing Status Prescription
ATC Code B01AC09
DrugBank ID DB01240
KEGG ID D00106
MeSH ID D011464
PubChem ID 5282411
TTD Drug ID D0V0IX
NDC Product Code 62756-059; 66215-402; 66215-403; 62287-123; 62756-060
Synonyms Epoprostenol | Epoprostanol | Prostaglandin I2 | Prostacyclin | Prostaglandin I(2) | Veletri | Epoprostenol Sodium | Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer | Flolan
Chemical Information
Molecular Formula C20H32O5
CAS Registry Number 35121-78-9
SMILES CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)O2)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Neoplasm malignant16.16.01.001--Not Available
Nephrolithiasis20.04.01.0020.000927%
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.003--Not Available
Neuralgia17.02.07.0050.000371%
Neuropathy peripheral17.09.03.003--Not Available
Night sweats23.02.03.006; 08.01.03.0310.000371%Not Available
Oedema14.05.06.010; 08.01.07.0060.004081%Not Available
Oedema peripheral02.05.04.007; 14.05.06.011; 08.01.07.0070.004452%
Oesophageal haemorrhage24.07.02.021; 07.12.01.0020.000371%
Orthopnoea02.01.03.006; 22.02.01.0200.000556%Not Available
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Oxygen saturation decreased13.02.01.0040.003524%Not Available
Pain08.01.08.0040.005565%
Pain in extremity15.03.04.0100.008347%
Pain in jaw15.02.01.0030.021332%Not Available
Pain of skin23.03.03.0030.000371%
Pallor23.03.03.031; 08.01.03.032; 24.03.04.0010.000927%Not Available
Palpitations02.01.02.0030.005194%
Pancreatitis07.18.01.0010.000742%
Pancytopenia01.03.03.0030.002040%Not Available
Panic attack19.06.04.0010.000371%Not Available
Papule23.03.03.0380.000371%Not Available
Paraesthesia17.02.06.005--
Pericardial effusion02.06.01.0020.001298%
Peripheral vascular disorder24.03.01.003--Not Available
Peritonitis11.01.07.007; 07.19.05.0040.000097%
Pharyngeal oedema23.04.01.016; 22.04.05.003; 10.01.05.0160.000742%Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.0040.000371%
Pharyngitis streptococcal22.07.04.001; 11.02.06.0020.000371%Not Available
The 8th Page    First    Pre   8 9 10 11 12    Next   Last    Total 15 Pages