Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Emtricitabine
Drug ID BADD_D00766
Description Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) indicated for the treatment of HIV infection in adults[L9019] or combined with [tenofovir alafenamide] for the prevention of HIV-1 infection in high risk adolescents and adults.[L9010] Emtricitabine is a cytidine analogue.[L9019] The drug works by inhibiting HIV reverse transcriptase, preventing transcription of HIV RNA to DNA.[L9019] Emtricitabine was granted FDA approval on 2 July 2003.[L9019]
Indications and Usage Indicated, in combination with other antiretroviral agents, for the treatment of HIV-1 infection in adults and for postexposure prophylaxis of HIV infection in health care workers and others exposed occupationally or nonoccupationally via percutaneous injury or mucous membrane or nonintact skin contact with blood, tissues, or other body fluids associated with risk for transmission of the virus.
Marketing Status Prescription
ATC Code J05AF09
DrugBank ID DB00879
KEGG ID D01199
MeSH ID D000068679
PubChem ID 60877
TTD Drug ID D0S9SD
NDC Product Code 68554-0064; 70518-1847; 59997-0005; 42385-304; 72761-008; 69097-642; 52696-0008; 65862-305; 70518-2906; 42385-710; 49711-1516; 61958-0601; 69037-0003; 66721-400; 65015-838; 33342-500; 53104-7637; 68554-0027; 70966-0024; 65015-827; 61958-0602; 65015-883; 66406-0209
Synonyms Emtricitabine | Beta-L-2',3'-dideoxy-5-fluoro-3'-thiacytidine | Beta L 2',3' dideoxy 5 fluoro 3' thiacytidine | Coviracil | Emtriva
Chemical Information
Molecular Formula C8H10FN3O3S
CAS Registry Number 143491-57-0
SMILES C1C(OC(S1)CO)N2C=C(C(=NC2=O)N)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hyperbilirubinaemia14.11.01.010; 09.01.01.003; 01.06.04.003--Not Available
Hypercalcaemia14.04.01.003; 05.04.01.0020.008555%
Hypercholesterolaemia14.08.01.001--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperlactacidaemia14.01.01.006--Not Available
Hypersensitivity10.01.03.003--
Hypertriglyceridaemia14.08.02.001--
Hypokalaemia14.05.03.002--
Hypophosphataemia14.04.03.0010.025664%
Hypotension24.06.03.0020.005579%
Immune system disorder10.02.01.001--Not Available
Infection11.01.08.002--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Insulin resistance14.06.02.003; 05.06.02.003--Not Available
Lactic acidosis14.01.01.0020.005579%Not Available
Lipase increased13.05.01.003--
Liver abscess11.01.18.001; 09.01.11.0010.012832%Not Available
Multiple fractures15.08.02.005; 12.04.02.009--Not Available
Muscular weakness17.05.03.005; 15.05.06.001--
Myalgia15.05.02.001--
Myopathy15.05.05.001--Not Available
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Nephrogenic diabetes insipidus20.05.03.010; 14.05.07.002--Not Available
Nephropathy toxic20.05.03.002; 12.03.01.0100.017109%Not Available
Nervous system disorder17.02.10.001--Not Available
Neuritis17.09.03.001--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.0040.017109%Not Available
Neutrophil count decreased13.01.06.010--
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