| ADR Ontology |
| ADR Term |
Motor neurone disease |
| ADR ID |
BADD_A02853 |
| ADR Hierarchy |
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| Description |
Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089) [MeSH] |
| MedDRA Code |
10028003 |
| MeSH ID |
D016472
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ADR Severity Grade (FAERS)
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ADR Severity Grade (CTCAE)
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Not Available
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| Synonym |
| Motor neuron disease | Motor neurone disease | Other motor neuron diseases | Motor Neuron Disease | Motor Neuron Diseases | Neuron Disease, Motor | Neuron Diseases, Motor | Motor System Disease | Motor System Diseases | Familial Motor Neuron Disease | Motor Neuron Disease, Familial | Lateral Sclerosis | Lateral Scleroses | Scleroses, Lateral | Sclerosis, Lateral | Primary Lateral Sclerosis | Lateral Scleroses, Primary | Lateral Sclerosis, Primary | Primary Lateral Scleroses | Scleroses, Primary Lateral | Sclerosis, Primary Lateral | Motor Neuron Disease, Upper | Upper Motor Neuron Disease | Motor Neuron Disease, Secondary | Secondary Motor Neuron Disease | Anterior Horn Cell Disease | Motor Neuron Disease, Lower | Lower Motor Neuron Disease |
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| ADR Related Proteins |
| Protein Name |
UniProt AC |
TTD Target ID |
| Not Available | Not Available | Not Available |
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| Drugs Leading to the ADR |
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