Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Danazol
Drug ID BADD_D00576
Description A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.
Indications and Usage For the treatment of endometriosis and fibrocystic breast disease (in patients unresponsive to simple measures). Also used for the prophylactic treatment of all types of hereditary angioedema in males and females.
Marketing Status Prescription; Discontinued
ATC Code G03XA01
DrugBank ID DB01406
KEGG ID D00289
MeSH ID D003613
PubChem ID 28417
TTD Drug ID D09IPV
NDC Product Code 0527-1392; 53104-7501; 49076-5201; 0527-1369; 71052-662; 62991-2832; 42291-243; 0555-0635; 0555-0633; 38779-0174; 49452-2436; 0555-0634; 0527-1368; 71205-861; 71205-862
Synonyms Danazol | Danazant | Panacrine | Danocrine | Ladogal | Cyclomen | Danatrol | Danol | Danoval | Norciden | Azol | Danazol-Ratiopharm | Danazol Ratiopharm
Chemical Information
Molecular Formula C22H27NO2
CAS Registry Number 17230-88-5
SMILES CC12CCC3C(C1CCC2(C#C)O)CCC4=CC5=C(CC34C)C=NO5
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
ThrombophlebitisProtein kinase C delta typeQ05655T448613840287; 2363094; 8800154; 2146406
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Death08.04.01.001--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.016230%
Dyspepsia07.01.02.001--
Dysphonia22.02.05.005; 19.19.03.002; 17.02.08.004--
Enlarged clitoris21.08.02.001; 05.05.01.004--Not Available
Enzyme abnormality14.11.01.015--Not Available
Eosinophilia01.02.04.001--
Epilepsy17.12.03.002--Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Fatigue08.01.01.0020.002823%
Feeling abnormal08.01.09.0140.016230%Not Available
Fluid retention20.01.02.003; 14.05.06.002--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Gastroenteritis11.01.07.004; 07.19.03.001--Not Available
Gingival bleeding24.07.02.010; 07.09.07.001--Not Available
Glucose tolerance test abnormal13.02.02.011--Not Available
Guillain-Barre syndrome17.09.01.001; 11.07.01.001; 10.04.10.005--
Haematuria24.07.01.047; 20.02.01.006--
Haemoglobin13.01.05.018--Not Available
Headache17.14.01.0010.027051%
Hepatic adenoma09.04.01.002; 16.06.01.002--Not Available
Hepatic failure09.01.03.0020.002823%
Hepatic function abnormal09.01.02.001--Not Available
Hepatic neoplasm16.07.03.001; 09.04.03.001--Not Available
Hereditary angioedema23.04.01.015; 10.01.05.012; 03.02.01.0080.043281%Not Available
Hirsutism23.02.04.001; 05.05.01.005--
Hyperhidrosis23.02.03.004; 08.01.03.0280.010820%
Hypertension24.08.02.0010.010820%
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