Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cyproterone acetate
Drug ID BADD_D00555
Description An anti-androgen that, in the form of its acetate (cyproterone acetate), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females.
Indications and Usage For the palliative treatment of patients with advanced prostatic carcinoma.
Marketing Status Not Available
ATC Code G03HA01
DrugBank ID DB04839
KEGG ID D01368
MeSH ID D017373
PubChem ID 9880
TTD Drug ID Not Available
NDC Product Code 59010-000; 46439-8720; 53104-7635
Synonyms Cyproterone Acetate | Cyproterone Acetate, (17 alpha)-Isomer | Cyproterone Acetate, (1 alpha,2 alpha,9 beta,10 alpha)-Isomer | Androcur | Cyproterone Acetate, (1 alpha,2 alpha)-Isomer
Chemical Information
Molecular Formula C24H29ClO4
CAS Registry Number 427-51-0
SMILES CC(=O)C1(CCC2C1(CCC3C2C=C(C4=CC(=O)C5CC5C34C)Cl)C)OC(=O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Muscular weakness17.05.03.005; 15.05.06.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Nausea07.01.07.001--
Neoplasm16.16.02.001--Not Available
Nitrogen balance negative13.13.01.010--Not Available
Normochromic normocytic anaemia01.03.02.005--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Optic atrophy06.09.02.001--Not Available
Optic neuritis10.04.10.002; 06.04.08.002; 17.04.05.001--Not Available
Osteoporosis15.02.03.002; 14.04.04.002--
Pancreatitis07.18.01.001--
Personality disorder19.05.02.002--Not Available
Phlebitis24.05.03.001; 12.02.01.002--
Photosensitivity reaction23.03.09.003--
Pollakiuria20.02.02.007--
Pruritus23.03.12.001--
Pulmonary embolism24.01.06.001; 22.06.02.001--Not Available
Pulmonary fibrosis22.01.02.006--
Rash23.03.13.001--Not Available
Rash generalised23.03.13.002--Not Available
Rash maculo-papular23.03.13.004--
Renal failure20.01.03.005--Not Available
Retinal disorder06.08.03.005--Not Available
Retinal vascular disorder24.03.07.002; 06.10.01.002--
Retinal vein thrombosis24.01.07.002; 06.10.01.003--Not Available
Scleroderma23.03.02.005; 15.06.01.002; 10.04.07.001--Not Available
Shock24.06.02.002--Not Available
Skin discolouration23.03.03.005--Not Available
Skin disorder23.03.03.007--Not Available
Skin striae23.01.05.002--Not Available
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