Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cyclobenzaprine
Drug ID BADD_D00545
Description Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961[A185039] and has been available for human use since 1977.[A184982] It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond.[A185039,A184982] Since its approval, it has remained relatively popular as an adjunctive, short-term treatment for acute skeletal muscle spasms secondary to musculoskeletal injury.
Indications and Usage For use as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions.
Marketing Status Prescription; Discontinued
ATC Code M03BX08
DrugBank ID DB00924
KEGG ID D07758
MeSH ID C004704
PubChem ID 2895
TTD Drug ID D01KHH
NDC Product Code 68071-3150; 63187-812; 0615-8084; 61919-305; 69097-845; 69097-846; 51927-0118; 70518-0635; 58118-0846; 53002-3080; 53002-0521; 67296-1728; 70518-3159; 68071-3154; 60687-558; 50090-3253; 70934-005; 70518-0082
Synonyms cyclobenzaprine | Flexeril | Lisseril | cyclobenzaprine hydrochloride
Chemical Information
Molecular Formula C20H21N
CAS Registry Number 303-53-7
SMILES CN(C)CCC=C1C2=CC=CC=C2C=CC3=CC=CC=C31
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pollakiuria20.02.02.007--
Porphyria acute19.07.03.003; 17.19.01.001; 14.14.01.002; 09.01.10.001; 03.08.01.0020.000098%Not Available
Pruritus23.03.12.0010.000164%
Pulmonary embolism24.01.06.001; 22.06.02.0010.000098%Not Available
Purpura24.07.06.005; 23.06.01.004; 01.01.04.003--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Rash generalised23.03.13.0020.000098%Not Available
Rash pruritic23.03.12.0020.000066%Not Available
Rectal haemorrhage24.07.02.018; 07.12.03.0010.000066%
Respiratory arrest22.02.01.0090.000163%Not Available
Respiratory depression22.02.01.010; 17.02.05.0470.000051%Not Available
Sedation17.02.04.0050.000164%Not Available
Seizure17.12.03.0010.000394%
Sensory loss17.02.07.007--Not Available
Serotonin syndrome17.05.02.004; 15.05.04.016; 12.03.01.0410.000066%Not Available
Sexual dysfunction21.03.02.003; 19.08.05.0020.000066%Not Available
Shock24.06.02.0020.000098%Not Available
Sinus tachycardia02.03.03.0100.000164%
Sleep apnoea syndrome19.02.05.002; 22.02.01.013; 17.15.05.0010.000066%
Somnolence19.02.05.003; 17.02.04.0060.000754%
Status epilepticus17.12.03.0050.000066%Not Available
Stomatitis07.05.06.005--
Suicide attempt19.12.01.0040.000689%
Swollen tongue23.04.01.014; 10.01.05.015; 07.14.02.003--Not Available
Syncope17.02.04.008; 24.06.02.012; 02.01.02.0080.000164%
Tachycardia02.03.02.0070.000131%Not Available
Tension19.06.02.005--Not Available
Testicular swelling21.13.01.003--Not Available
Thinking abnormal19.10.03.001; 17.02.05.023--Not Available
The 5th Page    First    Pre   5 6 7    Next   Last    Total 7 Pages