Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ceftriaxone
Drug ID BADD_D00405
Description Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic.[A215582] It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges[A215582], eyes[A215647], and inner ear[A215627]. Ceftriaxone has broader and stronger gram-negative coverage then first or second-generation cephalosporins, but worse activity against methicillin-susceptible S.aureus. Ceftriaxone is a commonly used antimicrobial due to its good activity against multi-drug resistant Enterobacteriaceae, its relatively safe adverse effect profile, and its long half-life which allows for the convenience of daily or twice-daily dosing.[A215582]
Indications and Usage For the treatment of the infections (respiratory, skin, soft tissue, UTI, ENT) caused by S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph
Marketing Status Prescription; Discontinued
ATC Code J01DD04
DrugBank ID DB01212
KEGG ID D07659
MeSH ID D002443
PubChem ID 5479530
TTD Drug ID D07ACT
NDC Product Code 66794-214; 71205-593; 68071-4713; 44567-702; 66794-215; 70518-3355; 68180-633; 0143-9859; 50090-0945; 63187-435; 66794-213; 64679-702; 64679-701; 25021-106; 0143-9678; 68180-622; 25021-105; 66794-212; 25021-107; 0264-3155; 44567-700; 64679-703; 66794-211; 44567-703; 0143-9856; 71205-117; 0143-9858; 68071-4715; 72572-061; 68180-611; 68071-4304; 64679-983; 68071-4303; 44567-701; 0264-3153; 0143-9857; 63323-346; 68180-644; 72572-062; 50090-2628
Synonyms Ceftriaxone | Ceftriaxon | Cefatriaxone | Ceftriaxone, Disodium Salt, Hemiheptahydrate | Ceftrex | Ceftriaxon Curamed | Ceftriaxon Hexal | Ceftriaxona Andreu | Ceftriaxona LDP Torlan | Ceftriaxone Irex | Ceftriaxone Sodium | Ceftriaxone Sodium, Anhydrous | Anhydrous Ceftriaxone Sodium | Lendacin | Longacef | Longaceph | Ro13-9904 | Ro13 9904 | Ro139904 | Ro-13-9904 | Ro 13-9904 | Ro 13 9904 | Ro 139904 | Rocephin | Rocefalin | Rocephine | Rocefin | Tacex | Terbac | Ceftriaxone, Disodium Salt | Benaxona | Cefaxona
Chemical Information
Molecular Formula C18H18N8O7S3
CAS Registry Number 73384-59-5
SMILES CN1C(=NC(=O)C(=O)N1)SCC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Drug hypersensitivity10.01.01.0010.602562%Not Available
Drug interaction08.06.03.001--Not Available
Dysgeusia17.02.07.003; 07.14.03.001--
Dyskinesia17.01.02.0060.040852%
Dyspepsia07.01.02.0010.071490%
Dysphagia07.01.06.003--
Dysphonia22.02.05.005; 19.19.03.002; 17.02.08.0040.071490%
Dyspnoea22.02.01.004; 02.01.03.0020.796608%
Dystonia17.01.03.0010.030639%Not Available
Dysuria20.02.02.002--
Eczema23.03.04.0060.030639%
Electrocardiogram QT prolonged13.14.05.0040.081703%
Electrocardiogram ST segment elevation13.14.05.0250.040852%Not Available
Electroencephalogram abnormal13.07.03.0010.030639%Not Available
Encephalopathy17.13.02.0010.102129%
Enteritis07.08.03.0020.020426%
Enterocolitis07.08.03.003--
Eosinophil count increased13.01.06.0040.020426%Not Available
Eosinophilia01.02.04.0010.132768%
Eosinophilic pneumonia01.02.04.003; 22.01.01.0040.020426%Not Available
Epistaxis24.07.01.005; 22.04.03.0010.102129%
Erythema23.03.06.0010.561711%Not Available
Erythema multiforme23.03.01.003; 10.01.03.0150.071490%
Eye disorder06.08.03.0010.020426%Not Available
Eye irritation06.04.05.003--Not Available
Eye swelling06.08.03.0030.030639%Not Available
Eyelid oedema23.04.01.003; 10.01.05.001; 06.04.04.0040.040852%Not Available
Face oedema08.01.07.003; 23.04.01.004; 10.01.05.0020.061278%
Fatigue08.01.01.002--
Febrile neutropenia08.05.02.004; 01.02.03.002--
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