Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cefpodoxime proxetil
Drug ID BADD_D00396
Description Cefpodoxime is an oral third generation cephalosporin antibiotic with effectiveness against most Gram positive and Gram negative bacteria. Commonly used to treat acute otitis media, pharyngitis, and sinusitis, cefpodoxime proxetil is a prodrug which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime.
Indications and Usage For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms.
Marketing Status Prescription; Discontinued
ATC Code J01DD13
DrugBank ID DB01416
KEGG ID D00920
MeSH ID C053267
PubChem ID 6321414
TTD Drug ID Not Available
NDC Product Code 61788-5000; 65862-095; 16714-403; 16714-394; 69043-006; 65862-381; 16714-402; 65862-140; 69043-007; 65862-096; 0781-5439; 64980-403; 16714-395; 65862-141; 55289-393; 0781-5438; 63785-112; 64980-402; 57297-100
Synonyms cefpodoxime proxetil | 1-(isopropoxycarbonyloxy)ethyl-7-(2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetamido)-3-methoxymethyl-8-oxo-5-thia-1-azabicyclo(4,2,0)-oct-2-ene-2-carboxylate | Vantin | U 76252 | U-76,252 | cephalosporin 807 | CS 807 | CS-807 | Doxef
Chemical Information
Molecular Formula C21H27N5O9S2
CAS Registry Number 87239-81-4
SMILES CC(C)OC(=O)OC(C)OC(=O)C1=C(CSC2N1C(=O)C2NC(=O)C(=NOC)C3=CSC(=N3)N)COC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Rash23.03.13.001--Not Available
Rash maculo-papular23.03.13.004--
Rectal haemorrhage07.12.03.001; 24.07.02.018--
Rhinitis22.07.03.006; 11.01.13.004--
Serum sickness-like reaction10.01.03.005; 08.01.03.003--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Stevens-Johnson syndrome10.01.03.020; 23.03.01.007; 12.03.01.014; 11.07.01.005--
Stomatitis07.05.06.005--
Thrombocytopenia01.08.01.002--Not Available
Thrombocytopenic purpura23.06.01.007; 01.08.01.003--Not Available
Thrombocytosis01.08.02.001--Not Available
Toxic epidermal necrolysis10.01.01.006; 23.03.01.008; 12.03.01.015; 11.07.01.006--
Urticaria23.04.02.001; 10.01.06.001--
Vomiting07.01.07.003--
Skin candida23.09.02.006; 11.03.03.010--Not Available
Haemorrhage24.07.01.002--Not Available
Blood alkaline phosphatase increased13.04.02.004--
Coombs test positive13.01.01.002--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Renal impairment20.01.03.010--Not Available
Liver injury12.01.02.003; 09.01.07.022--Not Available
Foetal exposure during pregnancy18.08.05.001; 12.03.07.001--Not Available
Candida infection11.03.03.021--
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