Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cefazolin
Drug ID BADD_D00382
Description A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
Indications and Usage Mainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria. May be used for surgical prophylaxis; if required metronidazole may be added to cover B. fragilis.
Marketing Status Prescription; Discontinued
ATC Code J01DB04
DrugBank ID DB01327
KEGG ID D02299
MeSH ID D002437
PubChem ID 33255
TTD Drug ID D09KDN
NDC Product Code 71872-7141; 0781-3450; 50090-4256; 44567-706; 72572-055; 71872-7027; 0143-9665; 0404-9833; 67184-1001; 0143-9924; 0143-9983; 60505-6142; 52584-923; 0143-9261; 44567-707; 0781-3452; 0781-3451; 70518-3047; 67184-0560; 17337-0300; 0143-9262; 0404-9834; 52584-087; 0143-9923; 60505-6231; 52584-924; 44567-120; 0404-9835; 72572-056; 0409-2585; 60505-6143; 44567-708
Synonyms Cefazolin | Cephazolin | Cefamedin | Cefamezine | Cephamezine | Gramaxin | Kefzol | Totacef | Ancef | Cefazolin Sodium | Sodium, Cefazolin | Sodium Cephazolin | Cephazolin, Sodium | Cephazolin Sodium | Sodium, Cephazolin
Chemical Information
Molecular Formula C14H14N8O4S3
CAS Registry Number 25953-19-9
SMILES CC1=NN=C(S1)SCC2=C(N3C(C(C3=O)NC(=O)CN4C=NN=N4)SC2)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Eyelid oedema23.04.01.003; 10.01.05.001; 06.04.04.0040.000213%Not Available
Face oedema08.01.07.003; 23.04.01.004; 10.01.05.0020.000319%
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Feeling hot08.01.09.0090.000319%Not Available
Flatulence07.01.04.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.0250.000745%
Folliculitis23.09.04.007; 11.01.12.0180.000426%
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.0010.000426%Not Available
Gastrointestinal pain07.01.05.005--
Genital candidiasis21.10.03.001; 11.03.03.002--Not Available
Glomerulonephritis20.05.01.001; 10.02.01.0060.000213%Not Available
Haematemesis24.07.02.011; 07.12.02.0020.000213%Not Available
Haematuria24.07.01.047; 20.02.01.0060.000213%
Haemoglobin13.01.05.018--Not Available
Haemoglobin decreased13.01.05.003--Not Available
Haemolytic anaemia01.06.03.002--Not Available
Headache17.14.01.001--
Hepatic function abnormal09.01.02.001--Not Available
Hepatic steatosis14.08.04.005; 09.01.07.0030.000213%Not Available
Hepatitis09.01.07.004--Not Available
Hepatitis acute09.01.07.0050.000532%Not Available
Hepatitis cholestatic09.01.01.0020.000213%Not Available
Hyperhidrosis23.02.03.004; 08.01.03.0280.000319%
Hyperkinesia17.01.02.008--Not Available
Hypersensitivity10.01.03.0030.000958%
Hypersensitivity vasculitis10.02.02.017; 01.01.04.008; 24.05.02.012; 23.06.02.0050.000852%Not Available
Hypertension24.08.02.001--
Hypertonia17.05.02.001; 15.05.04.007--Not Available
Hyponatraemia14.05.04.0020.000213%
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