Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cabergoline
Drug ID BADD_D00329
Description Cabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome. Cabergoline possesses potent agonist activity on dopamine D2 receptors.
Indications and Usage For the treatment of hyperprolactinemic disorders, either idiopathic or due to prolactinoma (prolactin-secreting adenomas). May also be used to manage symptoms of Parkinsonian Syndrome as monotherapy during initial symptomatic management or as an adjunct to levodopa therapy during advanced stages of disease.
Marketing Status Prescription; Discontinued
ATC Code G02CB03; N04BC06
DrugBank ID DB00248
KEGG ID D00987
MeSH ID D000077465
PubChem ID 54746
TTD Drug ID D04EGX
NDC Product Code 40016-011; 49884-673; 14096-153; 50090-3951; 47848-009; 50742-118; 50090-3157; 59762-1005; 50090-5834; 0093-5420
Synonyms Cabergoline | 1-((6-allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea | FCE 21336 | FCE-21336 | Cabaser | Cabaseril | Dostinex | Galastop | Cabergoline Diphosphate | 1-Ethyl-2-(3'-dimethylaminopropyl)-3-(6'-allylergoline-8'-beta-carbonyl)urea diphosphate
Chemical Information
Molecular Formula C26H37N5O2
CAS Registry Number 81409-90-7
SMILES CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gallbladder perforation09.03.02.002; 12.01.02.0050.022020%
Gastritis07.08.02.001--
Gastroduodenal ulcer07.04.02.005--Not Available
Gastrointestinal pain07.01.05.005--
Glucose tolerance impaired14.06.02.001; 05.06.02.0010.022020%
Gravitational oedema08.01.07.005; 02.05.04.014--Not Available
Haematoma24.07.01.0010.022020%
Haematuria24.07.01.047; 20.02.01.0060.033030%
Haemolytic anaemia01.06.03.0020.055051%Not Available
Hallucination19.10.02.002--
Headache17.14.01.0010.275253%
Heart rate increased13.14.04.0020.022020%Not Available
Hemianopia06.02.07.004; 17.17.01.012--Not Available
Hemiparesis17.01.04.0010.022020%
Hepatic function abnormal09.01.02.001--Not Available
Hydronephrosis20.01.05.0010.022020%Not Available
Hyperhidrosis08.01.03.028; 23.02.03.0040.066061%
Hyperprolactinaemia05.03.01.0020.022020%Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.0010.055051%
Hypokinesia17.01.02.0090.022020%Not Available
Hypotension24.06.03.0020.044040%
Hypothyroidism14.11.01.012; 05.02.03.0010.033030%
IIIrd nerve paralysis06.05.02.011; 17.04.02.0030.033030%Not Available
Increased appetite14.03.01.003; 08.01.09.0270.022020%Not Available
Influenza11.05.03.001; 22.07.02.0010.044040%Not Available
Influenza like illness08.01.03.010--
Insomnia19.02.01.002; 17.15.03.0020.044040%
Interstitial lung disease22.01.02.003; 10.02.01.0330.022020%Not Available
Intracranial pressure increased17.07.02.0020.022020%Not Available
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