Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bosutinib monohydrate
Drug ID BADD_D00287
Description Bosutinib is a Bcr-Abl kinase inhibitor for the treatment of Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML). Compared to other tyrosine kinase inhibitors, it has a more favourable hematologic toxicity profile. FDA approved on September 4, 2012.
Indications and Usage Treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) with resistance or intolerance to prior therapy in adult patients.
Marketing Status Not Available
ATC Code L01EA04
DrugBank ID DB06616
KEGG ID D09728
MeSH ID C471992
PubChem ID 11990828
TTD Drug ID D0OB0F
NDC Product Code 0069-0135; 0069-0136; 0069-0193; 63539-117
Synonyms bosutinib | SKI606 | SKI-606
Chemical Information
Molecular Formula C26H31Cl2N5O4
CAS Registry Number 918639-08-4
SMILES CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC.O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hepatic function abnormal09.01.02.001--Not Available
Hepatotoxicity12.03.01.008; 09.01.07.009--Not Available
Hyperkalaemia14.05.03.001--
Influenza22.07.02.001; 11.05.03.001--Not Available
Myalgia15.05.02.001--
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Neutropenia01.02.03.004--Not Available
Oedema08.01.07.006; 14.05.06.010--Not Available
Pain08.01.08.004--
Pancreatitis acute07.18.01.002--Not Available
Pericardial effusion02.06.01.002--
Pericarditis02.06.02.001--
Pleural effusion22.05.02.002--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pruritus23.03.12.001--
Pulmonary hypertension24.08.03.002; 22.06.01.001--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Renal failure20.01.03.005--Not Available
Respiratory failure22.02.06.002; 14.01.04.003--
Thrombocytopenia01.08.01.002--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Urticaria23.04.02.001; 10.01.06.001--
Vomiting07.01.07.003--
Gastrointestinal toxicity12.03.01.019; 07.08.03.006--Not Available
Decreased appetite08.01.09.028; 14.03.01.005--
Respiratory tract infection22.07.07.001; 11.01.08.017--Not Available
Exfoliative rash23.03.07.006--Not Available
Bone marrow failure01.03.03.005--
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