Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bosutinib
Drug ID BADD_D00286
Description Bosutinib is a Bcr-Abl kinase inhibitor for the treatment of Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML). Compared to other tyrosine kinase inhibitors, it has a more favourable hematologic toxicity profile. FDA approved on September 4, 2012.
Indications and Usage Treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) with resistance or intolerance to prior therapy in adult patients.
Marketing Status Not Available
ATC Code L01EA04
DrugBank ID DB06616
KEGG ID D03252
MeSH ID C471992
PubChem ID 5328940
TTD Drug ID D0OB0F
NDC Product Code 54893-0042; 54893-0048; 54893-0041; 46708-878
Synonyms bosutinib | SKI606 | SKI-606
Chemical Information
Molecular Formula C26H29Cl2N5O3
CAS Registry Number 380843-75-4
SMILES CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.002--Not Available
Neoplasm progression16.16.02.0050.004170%Not Available
Decreased appetite14.03.01.005; 08.01.09.0280.009591%
Renal function test abnormal13.13.01.0120.000799%Not Available
Ill-defined disorder08.01.03.0490.000533%Not Available
Inner ear disorder04.04.02.002--Not Available
Blood disorder01.05.01.0040.000278%Not Available
Disease progression08.01.03.0380.003336%
Disease recurrence08.01.03.0500.001332%Not Available
Drug intolerance08.06.01.0130.005595%Not Available
Occult blood positive13.05.02.0010.000533%Not Available
Pancreatic enzymes increased13.05.01.0040.000533%Not Available
Hepatobiliary disease09.01.08.003--Not Available
Respiratory tract infection viral22.07.07.002; 11.05.04.003--Not Available
Renal impairment20.01.03.0100.003996%Not Available
Respiratory tract infection22.07.07.001; 11.01.08.017--Not Available
Peripheral arterial occlusive disease24.04.03.0100.000533%Not Available
Hepatic enzyme abnormal13.03.01.0200.000533%Not Available
Blood count abnormal13.01.07.0010.001598%Not Available
Exfoliative rash23.03.07.006--Not Available
Bone marrow failure01.03.03.005--
Cytopenia01.03.03.0120.001598%Not Available
Liver injury12.01.02.003; 09.01.07.022--Not Available
Oral disorder07.05.01.0050.000533%Not Available
Traumatic liver injury12.01.02.008; 09.01.08.010--Not Available
Oropharyngeal pain22.02.05.022; 07.05.05.0040.001332%
Acute kidney injury20.01.03.016--
Candida infection11.03.03.0210.000533%
Faeces soft07.01.03.0080.000533%Not Available
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