Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Azathioprine
Drug ID BADD_D00195
Description Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection.[L11214] Azathiprine was granted FDA approval on 20 March 1968.[L11214]
Indications and Usage Azathioprine is indicated to treat rheumatoid arthritis and prevent renal transplant rejection.[L11214]
Marketing Status approved
ATC Code L04AX01
DrugBank ID DB00993
KEGG ID D00238
MeSH ID D001379
PubChem ID 2265
TTD Drug ID D07QCE
NDC Product Code 62991-2189; 65649-231; 67877-492; 68084-229; 68382-120; 51407-182; 68382-118; 72789-129; 46014-1110; 70771-1141; 60219-1076; 60219-2036; 60219-2037; 68382-003; 48954-909; 51927-0071; 68682-241; 70518-3544; 70771-1140; 51927-2258; 54766-590; 65841-602; 12780-0300; 38779-0312; 66122-0009; 42291-063; 68462-502; 71610-124; 42291-071; 68682-231; 70771-1139; 15308-0732; 49452-0783; 67877-493; 51552-0779; 65649-241; 67877-494; 67877-495; 68382-119; 42973-143
UNII MRK240IY2L
Synonyms Azathioprine | Azothioprine | Imurel | Imuran | Immuran | Azathioprine Sodium | Sodium, Azathioprine | Azathioprine Sodium Salt | Azathioprine Sulfate
Chemical Information
Molecular Formula C9H7N7O2S
CAS Registry Number 446-86-6
SMILES CN1C=NC(=C1SC2=NC=NC3=C2NC=N3)[N+](=O)[O-]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hepatic cyst16.06.02.001; 09.01.08.0080.000313%Not Available
Hepatic encephalopathy17.13.01.003; 09.01.03.0060.000627%Not Available
Hepatic failure09.01.03.0020.001723%
Hepatic fibrosis24.08.06.002; 09.01.04.0020.000627%Not Available
Hepatic function abnormal09.01.02.0010.001473%Not Available
Hepatic necrosis09.01.07.0020.000313%
Hepatic steatosis09.01.07.003; 14.08.04.0050.001316%Not Available
Hepatitis09.01.07.0040.002193%Not Available
Hepatitis acute09.01.07.0050.000627%Not Available
Hepatitis B11.05.28.003; 09.01.09.003--
Hepatitis cholestatic09.01.01.0020.002099%Not Available
Hepatitis toxic12.03.01.016; 09.01.07.0170.000313%Not Available
Hepatocellular injury09.01.07.0080.000783%Not Available
Hepatomegaly09.01.05.001--Not Available
Hepatosplenomegaly09.01.05.002; 01.09.03.0010.001097%Not Available
Hepatotoxicity09.01.07.009; 12.03.01.0080.003446%Not Available
Hernia08.01.04.0010.000627%Not Available
Herpes zoster23.11.05.005; 17.09.03.026; 11.05.02.003--
Hiatus hernia22.09.02.004; 07.16.01.001--Not Available
Hidradenitis23.02.03.0130.000783%Not Available
Hodgkin's disease16.31.01.001; 01.16.01.0010.000940%Not Available
Hodgkin's disease lymphocyte depletion type stage unspecified16.31.03.001; 01.16.03.001--Not Available
Hodgkin's disease lymphocyte predominance type stage unspecified01.16.04.001; 16.31.04.001--Not Available
Hydrocephalus17.07.01.0010.000313%
Hydrops foetalis18.03.02.0080.000940%Not Available
Hyperaesthesia23.03.03.080; 17.02.06.0040.000313%Not Available
Hypercalcaemia14.04.01.003; 05.04.01.002--
Hyperkeratosis23.01.01.0010.000627%
Hyperlactacidaemia14.01.01.0060.000470%Not Available
Hypersensitivity10.01.03.0030.008334%
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ADReCS-Target
Drug Name ADR Term Target
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