ADReCS

Pharmaceutical Information

Drug Name	Azathioprine
Drug ID	BADD_D00195
Description	Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index.[A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection.[L11214] Azathiprine was granted FDA approval on 20 March 1968.[L11214]
Indications and Usage	Azathioprine is indicated to treat rheumatoid arthritis and prevent renal transplant rejection.[L11214]
Marketing Status	approved
ATC Code	L04AX01
DrugBank ID	DB00993
KEGG ID	D00238
MeSH ID	D001379
PubChem ID	2265
TTD Drug ID	D07QCE
NDC Product Code	62991-2189; 65649-231; 67877-492; 68084-229; 68382-120; 51407-182; 68382-118; 72789-129; 46014-1110; 70771-1141; 60219-1076; 60219-2036; 60219-2037; 68382-003; 48954-909; 51927-0071; 68682-241; 70518-3544; 70771-1140; 51927-2258; 54766-590; 65841-602; 12780-0300; 38779-0312; 66122-0009; 42291-063; 68462-502; 71610-124; 42291-071; 68682-231; 70771-1139; 15308-0732; 49452-0783; 67877-493; 51552-0779; 65649-241; 67877-494; 67877-495; 68382-119; 42973-143
UNII	MRK240IY2L
Synonyms	Azathioprine \| Azothioprine \| Imurel \| Imuran \| Immuran \| Azathioprine Sodium \| Sodium, Azathioprine \| Azathioprine Sodium Salt \| Azathioprine Sulfate

Chemical Information

Molecular Formula	C9H7N7O2S
CAS Registry Number	446-86-6
SMILES	CN1C=NC(=C1SC2=NC=NC3=C2NC=N3)[N+](=O)[O-]
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Type 2 diabetes mellitus	14.06.01.003; 05.06.01.003	-	-	Not Available
Oral disorder	07.05.01.005	0.000846%		Not Available
Gastrointestinal sounds abnormal	07.01.01.002	-	-	Not Available
Skin mass	23.07.04.014	-	-	Not Available
Brain injury	19.07.03.007; 17.11.01.003	0.000470%		Not Available
Cholestatic liver injury	09.01.07.016	0.000470%		Not Available
Hypertransaminasaemia	09.01.02.005	0.000313%		Not Available
Anorectal discomfort	07.03.03.003	0.000313%		Not Available
Oropharyngeal pain	22.12.03.016; 07.05.05.004	0.002976%
X-linked lymphoproliferative syndrome	03.17.01.002; 01.13.02.003; 16.21.02.003; 11.05.10.005; 10.03.01.003	-	-	Not Available
Epstein-Barr virus associated lymphoproliferative disorder	01.13.02.002; 16.21.02.002; 11.05.10.001	0.000940%		Not Available
Acute kidney injury	20.01.03.016	0.003916%
Upper-airway cough syndrome	22.12.03.036	0.000627%
Foetal growth restriction	18.03.01.002	0.000470%
Gestational hypertension	24.08.07.004; 18.02.03.004	0.000470%		Not Available
Posterior reversible encephalopathy syndrome	17.13.02.007	0.001723%
Macular fibrosis	06.09.03.014	0.000470%		Not Available
Drug-induced liver injury	12.03.01.044; 09.01.07.023	0.002350%		Not Available
Granulomatosis with polyangiitis	24.12.04.011; 22.01.01.015; 20.05.01.013; 10.02.02.018	0.000470%		Not Available
Hepatocellular carcinoma	16.07.02.005; 09.04.02.010	0.000627%		Not Available
Drug reaction with eosinophilia and systemic symptoms	12.03.01.064; 23.03.05.005; 10.01.01.021	0.006423%		Not Available
Diffuse alopecia	23.02.02.007	0.000627%		Not Available
Autoimmune haemolytic anaemia	10.04.01.005; 01.06.01.004	0.000627%		Not Available
Faeces soft	07.01.03.008	0.000313%		Not Available
Mouth swelling	23.04.01.020; 10.01.05.020; 07.05.04.007	-	-	Not Available
Noninfective sialoadenitis	07.06.04.003	0.000313%		Not Available
Stenosis	08.01.03.060	0.000627%		Not Available
Multiple organ dysfunction syndrome	08.01.03.057	0.003446%
Anal incontinence	17.05.01.021; 07.01.06.029	0.000627%
Abdominal mass	07.01.01.003	-	-	Not Available

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