Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apomorphine
Drug ID BADD_D00152
Description Apomorphine is a non-ergoline dopamine D2 agonist indicated to treat hypomobility associated with Parkinson's. It was first synthesized in 1845 and first used in Parkinson's disease in 1884.[A203618] Apomorphine has also been investigated as an emetic, a sedative, a treatment for alcoholism, and a treatment of other movement disorders.[A203597,A203618] Apomorphine was granted FDA approval on 20 April 2004.[L13919]
Indications and Usage For the acute, intermittent treatment of hypomobility, off episodes (end-of-dose wearing off and unpredictable on/off episodes) associated with advanced Parkinson's disease.
Marketing Status Prescription; Discontinued
ATC Code G04BE07; N04BC07
DrugBank ID DB00714
KEGG ID D07460
MeSH ID D001058
PubChem ID 6005
TTD Drug ID D0H6QU
NDC Product Code Not Available
Synonyms Apomorphine | Apomorphine Hydrochloride, Anhydrous | Apomorphine Hydrochloride Anhydrous | Apomorphine Hydrochloride | Apomorphin-Teclapharm | Apomorphin Teclapharm | Apomorphine Hydrochloride, Hemihydrate | Apokinon | Apomorphine Chloride | Britaject
Chemical Information
Molecular Formula C17H17NO2
CAS Registry Number 58-00-4
SMILES CN1CCC2=C3C1CC4=C(C3=CC=C2)C(=C(C=C4)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionProtein c-FosP01100T2802511070194; 1347413; 7477877
Tremor (excl congenital)Fatty acid-binding protein, adipocyteQ9R290Not Available25933950
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Drooling17.02.05.0050.000849%Not Available
Dyskinesia17.01.02.0060.003396%
Dyspnoea22.02.01.004; 02.01.03.002--
Dystonia17.01.03.0010.001273%Not Available
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.001--Not Available
Eosinophilia01.02.04.0010.001273%
Epilepsy17.12.03.0020.000849%Not Available
Erythema23.03.06.0010.001273%Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.0140.000849%Not Available
Feeling hot08.01.09.0090.000849%Not Available
Flatulence07.01.04.0020.000849%
Flushing24.03.01.002; 23.06.05.003; 08.01.03.0250.000849%
Granuloma23.03.15.001; 08.01.05.001--Not Available
Haemoglobin decreased13.01.05.0030.000849%Not Available
Haemolysis01.06.04.0020.000849%
Haemolytic anaemia01.06.03.0020.006367%Not Available
Hallucination19.10.02.0020.003396%
Hallucination, visual19.10.02.0040.000849%Not Available
Headache17.14.01.001--
Heart rate increased13.14.04.0020.000849%Not Available
Hip fracture15.08.03.001; 12.04.01.0010.002122%
Hyperhidrosis23.02.03.004; 08.01.03.0280.001698%
Hypersensitivity10.01.03.0030.000849%
Hypertension24.08.02.0010.001273%
Hypotension24.06.03.0020.005094%
Hypotonia17.05.02.002; 15.05.04.0080.000849%Not Available
Ileus07.13.01.0010.000849%
Infection11.01.08.0020.001273%Not Available
Injection site reaction12.07.03.015; 08.02.03.014--
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