| ADR Ontology |
| ADR Term |
Amyotrophic lateral sclerosis |
| ADR ID |
BADD_A00177 |
| ADR Hierarchy |
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| Description |
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94) [MeSH] |
| MedDRA Code |
10002026 |
| MeSH ID |
D000690
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ADR Severity Grade (FAERS)
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ADR Severity Grade (CTCAE)
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Not Available
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| Synonym |
| Amyotrophic lateral sclerosis | ALS | Amyotrophic Lateral Sclerosis | Sclerosis, Amyotrophic Lateral | Charcot Disease | Motor Neuron Disease, Amyotrophic Lateral Sclerosis | Lou Gehrig Disease | Lou Gehrig's Disease | Lou-Gehrigs Disease | Disease, Lou-Gehrigs | ALS (Amyotrophic Lateral Sclerosis) | Gehrig's Disease | Gehrig Disease | Gehrigs Disease | Amyotrophic Lateral Sclerosis, Guam Form | Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam | Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam | Guam Form of Amyotrophic Lateral Sclerosis | Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1 | Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1 | Guam Disease | Disease, Guam | Amyotrophic Lateral Sclerosis With Dementia | Dementia With Amyotrophic Lateral Sclerosis |
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| ADR Related Proteins |
| Protein Name |
UniProt AC |
TTD Target ID |
| Not Available | Not Available | Not Available |
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| Drugs Leading to the ADR |
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