Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Amiodarone hydrochloride
Drug ID BADD_D00116
Description Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings.[A36817] Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxicity and possibly death, amiodarone use should be reserved for its approved indications, according to prescribing information.[L3561,L11265,L11286]
Indications and Usage Intravenously, for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation and hemodynamically unstable ventricular tachycardia in patients refractory to other therapy. Orally, for the treatment of life-threatening recurrent ventricular arrhythmias such as recurrent ventricular fibrillation and recurrent hemodynamically unstable ventricular tachycardia.
Marketing Status Prescription; Discontinued
ATC Code C01BD01
DrugBank ID DB01118
KEGG ID D00636
MeSH ID D000638
PubChem ID 441325
TTD Drug ID D0L5WM
NDC Product Code 71335-0881; 70518-1939; 72888-061; 51672-4056; 51662-1358; 68382-227; 0143-9875; 43066-360; 49632-080; 68083-112; 51672-4057; 71335-1297; 55150-181; 29300-359; 63629-7300; 55154-3365; 43066-150; 42494-309; 25021-302; 0904-6993; 65085-0022; 63629-2001; 0904-6556; 0245-1645; 70518-3246; 72888-039; 63739-051; 50090-3015; 72888-060; 17337-0403; 70518-2792; 66039-111; 70518-1231; 52584-153; 67457-153; 71335-1942; 50090-5766; 51862-240; 71872-7149; 71872-7000; 63629-2076; 50268-097; 16714-843; 14335-270; 0404-9815; 42494-308; 50090-5062; 55150-182; 16714-844; 0615-8258; 42494-307; 51862-241; 71872-7034; 55150-180; 51862-242; 50090-3496; 60687-437; 16714-845; 71872-7163; 71335-1985; 51672-4055; 63323-616; 0245-0145; 55154-8185; 0245-0144; 65841-631; 52584-063; 51672-4025; 42419-017; 0185-0144; 0245-0147; 70934-280; 51662-1205; 67544-570; 65862-732
Synonyms Amiodarone | Amiodarona | Amiodarone Hydrochloride | Hydrochloride, Amiodarone | Amiohexal | Aratac | Tachydaron | Corbionax | Cordarone | Amiodarex | Trangorex | Kordaron | Cordarex | L-3428 | L 3428 | L3428 | Ortacrone | Rytmarone | SKF 33134-A | SKF 33134 A | SKF 33134A | Amiobeta | Braxan
Chemical Information
Molecular Formula C25H30ClI2NO3
CAS Registry Number 19774-82-4
SMILES CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HaemorrhageCytochrome P450 2C9P11712T19244Not Available
HypotensionCytochrome P450 3A4P08684T37848Not Available
Liver injuryAlanine aminotransferase 1Q8QZR5Not AvailableNot Available
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
RhabdomyolysisCytochrome P450 3A4P08684T37848Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T49526Not Available
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T39716Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not AvailableNot Available
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T20251Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Thyroid neoplasm16.24.01.002; 05.02.05.002--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Tongue oedema10.01.05.008; 07.14.02.007; 23.04.01.009--Not Available
Toxic epidermal necrolysis23.03.01.008; 12.03.01.015; 10.01.01.006; 11.07.01.006--
Tremor17.01.06.002--
Urinary retention20.02.02.011--
Urinary tract malformation20.08.03.002; 03.06.02.003--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Vasculitis24.05.02.001; 10.02.02.006--
Ventricular tachycardia02.03.04.010--
Vision blurred17.17.01.010; 06.02.06.007--
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.003--
Wheezing22.03.01.009--
Inappropriate antidiuretic hormone secretion14.05.07.001; 05.03.03.001--Not Available
Pulmonary mass22.02.07.004--Not Available
Hepatic enzyme increased13.03.01.019--Not Available
Electrocardiogram change13.14.05.014--Not Available
Decreased appetite08.01.09.028; 14.03.01.005--
Erectile dysfunction21.03.01.007; 19.08.04.001--
Pulmonary toxicity22.01.02.007; 12.03.01.013--Not Available
Renal impairment20.01.03.010--Not Available
Bone marrow failure01.03.03.005--
Thyroid cancer16.24.03.001; 05.02.05.001--Not Available
Liver injury09.01.07.022; 12.01.02.003--Not Available
Acute kidney injury20.01.03.016--
Sinus node dysfunction02.03.03.017--
The 5th Page    First    Pre   5    Total 5 Pages