Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women.
Marketing Status Prescription; Discontinued
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cardiomyopathy02.04.01.0010.000505%Not Available
Cardiovascular disorder24.03.02.009; 02.01.01.0010.000343%Not Available
Carotid artery stenosis24.04.06.001; 17.08.02.0010.001617%Not Available
Carpal tunnel syndrome17.09.02.0010.003940%Not Available
Cataract06.06.01.0010.011215%
Cataract nuclear06.06.01.0050.000202%Not Available
Cataract subcapsular06.06.01.0020.000202%Not Available
Cellulitis11.02.01.001; 23.09.01.0010.006466%Not Available
Cerebral atrophy17.11.01.0010.000909%Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.003--Not Available
Cerebral infarction24.04.06.002; 17.08.01.004--Not Available
Cerebral ischaemia24.04.06.003; 17.08.01.0050.000404%
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Cerebrovascular disorder24.03.05.002; 17.08.02.0020.000211%Not Available
Cervical dysplasia21.06.01.0020.000404%Not Available
Cervical polyp21.06.02.004; 16.04.05.0010.000202%Not Available
Cervicobrachial syndrome17.10.02.001; 15.01.04.0020.000404%Not Available
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.0090.001718%Not Available
Chest pain08.01.08.002; 02.02.02.011; 22.02.08.0030.010710%Not Available
Chest X-ray abnormal13.19.02.0010.000202%Not Available
Chills15.05.03.016; 08.01.09.001--
Cholangitis09.02.01.0020.000202%Not Available
Cholecystitis09.03.01.001--
Cholecystitis acute09.03.01.0030.000505%Not Available
Cholecystitis chronic09.03.01.0040.000202%Not Available
Cholelithiasis09.03.01.0020.002627%Not Available
Chondrocalcinosis pyrophosphate15.01.06.003; 14.04.01.0100.000202%Not Available
Chorioretinitis11.01.06.010; 06.04.06.0030.000808%Not Available
Chronic obstructive pulmonary disease22.03.01.0070.002767%Not Available
Chronic sinusitis22.07.03.018; 11.01.13.0160.001010%Not Available
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