Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women.
Marketing Status Prescription; Discontinued
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood bilirubin increased13.03.01.008--
Blood calcium decreased13.11.01.0020.001414%Not Available
Blood calcium increased13.11.01.0030.001010%Not Available
Blood cholesterol13.12.01.0140.000202%Not Available
Blood cholesterol increased13.12.01.0020.015559%
Blood cortisol decreased13.10.09.0040.000202%Not Available
Blood creatine phosphokinase increased13.04.01.001--
Blood creatinine increased13.13.01.004--
Blood glucose abnormal13.02.02.0080.000606%Not Available
Blood glucose decreased13.02.02.0010.000404%Not Available
Blood glucose increased13.02.02.0020.001718%Not Available
Blood iron decreased13.11.01.0060.000404%Not Available
Blood lactate dehydrogenase increased13.04.02.002--
Blood magnesium decreased13.11.01.0080.000505%Not Available
Blood parathyroid hormone increased13.10.07.0020.000505%Not Available
Blood potassium decreased13.11.01.0100.001313%Not Available
Blood potassium increased13.11.01.0110.000505%Not Available
Blood pressure abnormal13.14.03.0010.000303%Not Available
Blood pressure decreased13.14.03.002--Not Available
Blood pressure increased13.14.03.0050.002930%Not Available
Blood sodium decreased13.11.01.0120.000303%Not Available
Blood sodium increased13.11.01.0130.000202%Not Available
Blood thyroid stimulating hormone decreased13.10.03.0110.000202%Not Available
Blood thyroid stimulating hormone increased13.10.03.0060.000202%
Blood triglycerides increased13.12.03.0010.001010%Not Available
Blood urea increased13.13.01.0060.000404%Not Available
Body temperature increased13.15.01.0010.000505%Not Available
Bone development abnormal15.02.04.0030.000202%Not Available
Bone disorder15.02.04.0040.039202%Not Available
Bone neoplasm16.29.01.001; 15.09.02.0010.000202%Not Available
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