Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Langerhans' cell histiocytosis
ADR ID BADD_A06574
ADR Hierarchy
01      Blood and lymphatic system disorders
01.13      Haematopoietic neoplasms (excl leukaemias and lymphomas)
01.13.04      Histiocytoses
01.13.04.003      Langerhans' cell histiocytosis
15      Musculoskeletal and connective tissue disorders
15.09      Musculoskeletal and connective tissue neoplasms
15.09.03      Malignant musculoskeletal and connective tissue neoplasms
15.09.03.008      Langerhans' cell histiocytosis
16      Neoplasms benign, malignant and unspecified (incl cysts and polyps)
16.21      Haematopoietic neoplasms (excl leukaemias and lymphomas)
16.21.04      Histiocytoses
16.21.04.003      Langerhans' cell histiocytosis
22      Respiratory, thoracic and mediastinal disorders
22.01      Lower respiratory tract disorders (excl obstruction and infection)
22.01.01      Lower respiratory tract inflammatory and immunologic conditions
22.01.01.016      Langerhans' cell histiocytosis
Description The most benign and common form of Langerhans-cell histiocytosis which involves localized nodular lesions predominantly of the bones but also of the gastric mucosa, small intestine, lungs, or skin, with infiltration by EOSINOPHILS. [MeSH]
MedDRA Code 10069698
MeSH ID D004803; D006646
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Eosinophilic granuloma | Histiocytosis X of lung | Langerhans' cell granulomatosis | Letterer-Siwe disease | Letterer-Siwe disease involving intra-abdominal lymph nodes | Letterer-Siwe disease involving intrapelvic lymph nodes | Letterer-Siwe disease involving intrathoracic lymph nodes | Letterer-Siwe disease involving lymph nodes of axilla and upper limb | Letterer-Siwe disease involving lymph nodes of head, face, and neck | Letterer-Siwe disease involving lymph nodes of inguinal region and lower limb | Letterer-Siwe disease involving lymph nodes of multiple sites | Letterer-Siwe disease involving spleen | Letterer-Siwe disease, unspecified site, extranodal and solid organ sites | Chronic idiopathic xanthomatosis | Hand-Schueller-Christian disease | Langerhans' cell histiocytosis | Eosinophilic Granuloma | Granuloma, Eosinophilic | Eosinophilic Granulomas | Granulomas, Eosinophilic
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00405Ceftriaxone0.020426%
BADD_D00511Clozapine0.005605%
BADD_D00566Dabrafenib0.001332%
BADD_D00616Desmopressin0.005881%
BADD_D00932Fluoxetine--
BADD_D01295Linezolid0.030187%
BADD_D01834Prednisone0.000060%
BADD_D02257Trametinib0.000139%
BADD_D02464Fingolimod0.001158%
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