Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Breakthrough pain
ADR ID BADD_A06248
ADR Hierarchy
08      General disorders and administration site conditions
08.01      General system disorders NEC
08.01.08      Pain and discomfort NEC
08.01.08.026      Breakthrough pain
16      Neoplasms benign, malignant and unspecified (incl cysts and polyps)
16.32      Neoplasm related morbidities
16.32.03      Oncologic complications and emergencies
16.32.03.016      Breakthrough pain
Description Acute pain that comes on rapidly despite the use of pain medication. [MeSH]
MedDRA Code 10064556
MeSH ID D059390
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Breakthrough pain | Breakthrough cancer pain | Breakthrough Pain | Breakthrough Pains | Pains, Breakthrough | Pain, Breakthrough
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00156Apremilast0.001737%
BADD_D00308Bupivacaine0.001970%
BADD_D00310Buprenorphine0.013010%
BADD_D00879Fentanyl0.006291%
BADD_D01096Hydromorphone--
BADD_D01498Morphine0.001171%
BADD_D01645Oxycodone0.000650%
BADD_D01835Pregabalin0.001062%
BADD_D02115Tapentadol0.008760%
BADD_D02236Tofacitinib0.002316%
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