Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hydromorphone
Drug ID BADD_D01096
Description Hydromorphone is a pure opioid,[A176468] a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 and 8. Due to these modifications, it presents a very high potency and comparable side effect profile to the parent compound.[A176471] Even though hydromorphone does not present a 6-hydroxyl group, it is categorized under the family of phenanthrenes and it is considered a chemical under the schedule II (medical purposes with high addiction potential).[A176495] The first reported approved product containing hydromorphone in the form of hydromorphone hydrochloride was developed by Fresenius Kabi USA and FDA approved in 1984.[L5795]
Indications and Usage For the relief of moderate to severe pain such as that due to surgery, cancer, trauma/injury, or burns.
Marketing Status Prescription; Discontinued
ATC Code N02AA03
DrugBank ID DB00327
KEGG ID D08047
MeSH ID D004091
PubChem ID 5284570
NDC Product Code Not Available
Synonyms Hydromorphone | Dihydromorphinone | Hydromorphon | Palladone | Laudacon | Dilaudid | Hydromorphone Hydrochloride
Chemical Information
Molecular Formula C17H19NO3
CAS Registry Number 466-99-9
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.0010.002064%
Abdominal pain07.01.05.0020.004128%
Abdominal pain upper07.01.05.003--
Abnormal dreams19.02.03.001; Available
Abnormal faeces07.01.03.001--Not Available
Accidental overdose12.06.03.002--Not Available
Addison's disease10.04.08.008;; Available
Aggression19.05.01.001--Not Available
Alcohol abuse19.07.02.007--Not Available
Alcoholism19.07.02.001--Not Available
Altered state of consciousness19.07.01.003; Available
Amylase increased13.05.01.009--
Anal fissure07.03.01.002--
Anaphylactic reaction24.06.03.006;
Anaphylactic shock24.06.02.004; Available
Anaphylactoid reaction24.06.03.007; Available
Angioedema23.04.01.001; Available
Apathy19.04.04.002--Not Available
Application site pain08.02.01.004; Available
Arrhythmia02.03.02.001--Not Available
Arthropathy15.01.01.003--Not Available
The 1th Page    1 2 3 4 5    Next   Last    Total 12 Pages