Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tapentadol
Drug ID BADD_D02115
Description Opioid analgesic for treatment of moderate to severe pain. FDA approved on Nov 20, 2008.
Indications and Usage The immediate-release formulation of tapentadol is indicated for the relief of moderate to severe acute pain. The long-acting formulation serves as a continuous, around-the-clock analgesic that is indicated for the relief of moderate to severe chronic pain or neuropathic pain associated with diabetic peripheral neuropathy.
Marketing Status Prescription
ATC Code N02AX06
DrugBank ID DB06204
KEGG ID D06007
MeSH ID D000077432
PubChem ID 9838022
TTD Drug ID D0K4MH
NDC Product Code Not Available
Synonyms Tapentadol | 3-((1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl)phenol | Nucynta | Tapentadol Hydrochloride
Chemical Information
Molecular Formula C14H23NO
CAS Registry Number 175591-23-8
SMILES CCC(C1=CC(=CC=C1)O)C(C)CN(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abnormal dreams19.02.03.001; 17.15.02.0010.014599%Not Available
Abortion spontaneous18.01.04.001--Not Available
Aggression19.05.01.0010.010220%Not Available
Agitation19.06.02.001; 17.02.05.0120.017519%
Akathisia19.06.02.006; 17.01.02.0020.002920%
Alanine aminotransferase increased13.03.01.003--
Alopecia23.02.02.001--
Altered state of consciousness19.07.01.003; 17.02.04.0010.010220%Not Available
Amnesia19.20.01.001; 17.03.02.0010.011680%
Anaphylactic reaction24.06.03.006; 10.01.07.0010.004380%
Aneurysm24.02.01.0010.000762%Not Available
Anxiety19.06.02.0020.026279%
Apnoea22.02.01.0010.008760%
Arrhythmia02.03.02.0010.004380%Not Available
Aspiration22.02.07.0070.000762%
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.0100.005840%Not Available
Ataxia17.02.02.001; 08.01.02.0040.002920%
Back pain15.03.04.005--
Bladder pain20.02.02.0010.002920%Not Available
Blister23.03.01.001; 12.01.06.0020.002920%Not Available
Blood glucose decreased13.02.02.0010.002920%Not Available
Blood glucose increased13.02.02.0020.004380%Not Available
Blood potassium decreased13.11.01.0100.002920%Not Available
Blood pressure decreased13.14.03.0020.007300%Not Available
Blood pressure increased13.14.03.0050.013140%Not Available
Blood sodium decreased13.11.01.0120.002920%Not Available
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