| ADR Ontology |
| ADR Term |
Progressive multifocal leukoencephalopathy |
| ADR ID |
BADD_A03557 |
| ADR Hierarchy |
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| Description |
An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7) [MeSH] |
| MedDRA Code |
10036807 |
| MeSH ID |
D007968
|
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ADR Severity Grade (FAERS)
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ADR Severity Grade (CTCAE)
|
Not Available
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| Synonym |
| Progressive multifocal leucoencephalopathy | Progressive multifocal leukoencephalopathy | Leukoencephalopathy, Progressive Multifocal | Leukoencephalopathies, Progressive Multifocal | Multifocal Leukoencephalopathies, Progressive | Multifocal Leukoencephalopathy, Progressive | Progressive Multifocal Leukoencephalopathies | Progressive Multifocal Leukoencephalopathy | JC Polyomavirus Encephalopathy | Encephalopathies, JC Polyomavirus | Encephalopathy, JC Polyomavirus | Encephalitis, JC Polyomavirus | JC Polyomavirus Encephalitis |
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| ADR Related Proteins |
| Protein Name |
UniProt AC |
TTD Target ID |
| Not Available | Not Available | Not Available |
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| Drugs Leading to the ADR |
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